- Random plasma glucose predicts the diagnosis of diabetes. [Journal Article]
- PlosPLoS One 2019; 14(7):e0219964
- CONCLUSIONS: RPG levels below the diabetes "diagnostic" range (≥200 mg/dl) provide good discrimination for follow-up diagnosis. Use of such levels-obtained opportunistically, during outpatient visits-could signal the need for further testing, allow preventive intervention in high risk individuals before onset of disease, and lead to earlier identification of diabetes.
- Pancreatic ductal cells may have a negative effect on human islet transplantation. [Journal Article]
- PlosPLoS One 2019; 14(7):e0220064
- CONCLUSIONS: Islet preparations enriched with ductal cells have a lower insulin stimulation index in vitro and achieved a worse metabolic outcome after transplantation. Inflammation may mediate the deleterious effects of ductal cells on islet cells.
- Eight-year trajectories of changes in health-related quality of life in knee osteoarthritis: Data from the Osteoarthritis Initiative (OAI). [Journal Article]
- PlosPLoS One 2019; 14(7):e0219902
- CONCLUSIONS: HRQoL worsening was associated with several risk factors; surgical and pharmacological interventions were more common in the poorer HRQoL trajectory groups indicating that HRQoL does reflect the need for OA treatment. These findings may have implications for targeting interventions to specific knee OA patient groups.
- Novel protective and risk loci in hip dysplasia in German Shepherds. [Journal Article]
- PGPLoS Genet 2019 Jul 19; 15(7):e1008197
- Canine hip dysplasia is a common, non-congenital, complex and hereditary disorder. It can inflict severe pain via secondary osteoarthritis and lead to euthanasia. An analogous disorder exists in huma…
Canine hip dysplasia is a common, non-congenital, complex and hereditary disorder. It can inflict severe pain via secondary osteoarthritis and lead to euthanasia. An analogous disorder exists in humans. The genetic background of hip dysplasia in both species has remained ambiguous despite rigorous studies. We aimed to investigate the genetic causes of this disorder in one of the high-risk breeds, the German Shepherd. We performed genetic analyses with carefully phenotyped case-control cohorts comprising 525 German Shepherds. In our genome-wide association studies we identified four suggestive loci on chromosomes 1 and 9. Targeted resequencing of the two loci on chromosome 9 from 24 affected and 24 control German Shepherds revealed deletions of variable sizes in a putative enhancer element of the NOG gene. NOG encodes for noggin, a well-described bone morphogenetic protein inhibitor affecting multiple developmental processes, including joint development. The deletion was associated with the healthy controls and mildly dysplastic dogs suggesting a protective role against canine hip dysplasia. Two enhancer variants displayed a decreased activity in a dual luciferase reporter assay. Our study identifies novel loci and candidate genes for canine hip dysplasia, with potential regulatory variants in the NOG gene. Further research is warranted to elucidate how the identified variants affect the expression of noggin in canine hips, and what the potential effects of the other identified loci are.
- Bright G-Quadruplex Nanostructures Functionalized with Porphyrin Lanterns. [Journal Article]
- JAJ Am Chem Soc 2019 Jul 19
- The intricate arrangement of numerous and closely placed chromophores on nanoscale scaffolds can lead to key photonic applications ranging from optical waveguides and antennas to signal-enhanced fluo…
The intricate arrangement of numerous and closely placed chromophores on nanoscale scaffolds can lead to key photonic applications ranging from optical waveguides and antennas to signal-enhanced fluorescent sensors. In this regard, the self-assembly of dye-appended DNA sequences into programmed photonic architectures is promising. However, the dense-packing of dyes can result in not only compromised DNA assembly (leading to ill-defined structures and precipitates) but also to essentially non-fluorescent systems (due to π-π aggregation). Here, we introduce a two-step "tether and mask" strategy wherein large porphyrin dyes are first attached to short G-quadruplex forming sequences and then reacted with per-O-methylated β-cyclodextrin (PMβCD) caps, to form supramolecular synthons featuring the porphyrin fluor fixed into a masked porphyrin lantern (PL) state, due to intramolecular host-guest interactions in water. The PL-DNA sequences can then be self-assembled into cyclic architectures or unprecedented G-wires tethered with hundreds of porphyrin dyes. Importantly, despite the closely arrayed PL units (~2 nm), the dyes behave as bright chromophores (up to 180-fold brighter than the analogues lacking the PMβCD masks). Since other self-assembling scaffolds, dyes, and host molecules can be used in this modular approach, this manuscript lays a general strategy for the bottom-up aqueous self-assembly of bright nanomaterials containing densely packed dyes.
- [THE RELEVANT ISSUES ON PROTECTING THE RIGHTS OF A PERSON IN RESPECT OF WHOM THE USE OF COMPULSORY MEASURES OF A MEDICAL CHARACTER IS INTENDED OR THEIR APPLICATION IS CONSIDERED]. [Journal Article]
- GMGeorgian Med News 2019; (290):150-157
- The aim of this manuscript is to identify the current issues relating to protecting the rights of a person in respect of whom the use of compulsory measures of a medical character is intended or thei…
The aim of this manuscript is to identify the current issues relating to protecting the rights of a person in respect of whom the use of compulsory measures of a medical character is intended or their application is considered. The complex of general scientific and special methods of legal science was used to achieve the goal of the study, solve the problems and prove the results of the research. The comparative legal method was used for analyzing the criminal procedural legislation of Ukraine, other countries and the practice of the European Court of Human Rights. The systematic structural method gave an opportunity to describe an order of closing a pre-trial investigation in criminal proceedings for the application of compulsory measures of a medical character. The formal logical (dogmatic) method lies at the basis of the definitions' formation in the framework of the research's subject. The statistical method was used for summarizing and working on the statistical reports, materials of investigative and judicial practice. Special attention to this issue is due to the fact that there exists a separate category of people committed a socially harmful act, stipulated by the Ukrainian law on crimtinal responsibility, who were found legally insane, or committed a criminal offense in a state of sanity, but have caught a mental illness before sentencing. According to this fact, there are additional guarantees for the protection of the rights of such persons in the Chapter 39 of the Criminal Procedural Code of Ukraine, which are fully consistent with the international legal standards. Due to the conducted research, it has been proposed the following: firstly, to provide for mandatory participation of the legal representative of the person in respect of whom the use of compulsory measures of a medical character is intended or their application is considered at the legislative level; secondly, to change the name of the procedural document, which completes the pre-trial investigation in the criminal proceedings on the application of compulsory medical measures to the decision allowing the court to resolve the issue of the application of compulsory measures of a medical character; thirdly, to determine the content of this resolution by clearly specifying the list of information that should be contained in such resolution.
- From β-hCG values to counseling in tubal pregnancy: what do women want? [Journal Article]
- GEGynecol Endocrinol 2019 Jul 19; :1-6
- Tubal pregnancy represents an entity that every gynecologist will encounter during professional life. Because of the high prevalence among the pregnant population, standardized protocols are needed i…
Tubal pregnancy represents an entity that every gynecologist will encounter during professional life. Because of the high prevalence among the pregnant population, standardized protocols are needed in order to choose the optimal strategy for each case. Accurate ultrasound pictures are supporting a more precise diagnosis of ectopic tubal pregnancy, the evolution of which should be closely monitored in follow-up with serial β-hCG values. Laparoscopy, intramuscular methotrexate, and active expectant management are all involved, however, tailoring the best treatment to the patient's needs is the challenge to focus on. This manuscript describes how in routinary practice an evidence-based diagnostic process should be the key factor to go for the best possible management. When possible, a longsighted less invasive approach should be preferred, aiming to preserve the patient's fertility for years to come. An optimal choice of the management should involve the patient or the couple in the decision-making process to reach the ultimate goal of compliance.
- The EU regulatory framework on genetically modified organisms (GMOs). [Journal Article]
- TRTransgenic Res 2019; 28(Suppl 2):169-174
- The European Union (EU) legislation on genetically modified organisms (GMOs) aims to ensure a high level of protection for human, animal and environmental health and a well-functioning EU internal ma…
The European Union (EU) legislation on genetically modified organisms (GMOs) aims to ensure a high level of protection for human, animal and environmental health and a well-functioning EU internal market. The framework regulates the release of GMOs into the environment and their use as, or in, food and feed. It has three main pillars: pre-market authorisation based on a prior risk assessment, traceability and labelling. Within this legal framework, the EU has authorised the placing on the market of 118 GMOs so far. These have been obtained through long-standing techniques of genetic modification, namely transgenesis. Following the adoption of the GMO legislation, new techniques of genetic modification, including new mutagenesis techniques, have been developed, which have raised questions regarding the applicability of the GMO legislation and attracted a lot of attention from stakeholders and the general public. This article provides an overview of EU GMO legislation and implementation of the EU Court of Justice ruling on organisms obtained by mutagenesis techniques, issued in July 2018. It also updates on the recent initiatives by the European Commission and EU Member States on new developments in biotechnology. The manuscript is based on the author's contribution at the OECD Conference on Genome Editing, Applications in Agriculture, Implications for Health, Environment and Regulation held in Paris on 28-29 June 2018. It is complemented with updated information.
- Flux enhancement of thin-film composite membrane by graphene oxide incorporation. [Journal Article]
- JEJ Environ Health Sci Eng 2019; 17(1):377-382
- Reverse Osmosis (RO) is a rapid-developing desalination technology; however, it suffers from inefficient energy consumption. To reduce energy consumption, in this study, reverse osmosis thin-film com…
Reverse Osmosis (RO) is a rapid-developing desalination technology; however, it suffers from inefficient energy consumption. To reduce energy consumption, in this study, reverse osmosis thin-film composite membrane (TFC) module was prepared and composed of m-phenylenediamine (MPD), graphene oxide, and 1,3,5-benzenetricarbonyl chloride (TMC) by interfacial polymerization on the surface of a polysulfone substrate. The graphene oxide was embedded in the mentioned thin-film composite by adding it to MPD aqueous solution to enhance permeation flux and, thus, reduce energy consumption. This study assessed the performance of the membrane using a lab-scale RO setup and evaluated permeability and salt rejection. The chemical properties of TFC were also analyzed using ATR-FTIR. Incorporating various concentrations (0, 20, 40, 60, and 80 ppm) of graphene oxide into the TFC was shown to improve water flux. Flux improvement of 50% was achieved by using graphene (80 ppm), while 10% of salt rejection was lost. These flux increases resulted from the changes in surface charge, surface roughness, and hydrophilicity due to the embedment of GO nanosheets. The simplicity of the method, compatibility of GO with polyamide membrane, and quite short-time reaction are the highlights of this technique for developing novel TFC membranes for water treatment.
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- Role of oral anticoagulant therapy for secondary prevention in patients with stable atherothrombotic disease manifestations. [Review]
- TATher Adv Hematol 2019; 10:2040620719861475
- Coronary artery disease and peripheral arterial disease are strong predictors of risk for a future ischemic event. Despite the utilization of effective secondary prevention strategies, the prevalence…
Coronary artery disease and peripheral arterial disease are strong predictors of risk for a future ischemic event. Despite the utilization of effective secondary prevention strategies, the prevalence of ischemic recurrences remains high, underscoring the need for effective secondary prevention antithrombotic treatment regimens. To date, most of the tested approaches have been with the use of antiplatelet therapies, used either individually or in combination. However, most recent findings support the potential role of oral anticoagulant therapy in addition to antiplatelet therapy to reduce the risk of ischemic recurrences. This approach has been tested in both acute and stable settings of patients with cardiovascular disease manifestations. The present manuscript provides an overview on the rationale and clinical trial updates on the role of oral anticoagulant therapy, in particular rivaroxaban used at the so-called vascular protection dose, in adjunct to antiplatelet therapy (i.e. aspirin), a strategy known as dual pathway inhibition, for secondary prevention of ischemic recurrences in patients with stable atherosclerotic disease manifestations.