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1,121,049 results
  • PBT-6, a Novel PI3KC2γ Inhibitor in Rheumatoid Arthritis. [Journal Article]
    Biomol Ther (Seoul) 2019Kim J, Jung KH, … Hong SS
  • Phosphoinositide 3-kinase (PI3K) is considered as a promising therapeutic target for rheumatoid arthritis (RA) because of its involvement in inflammatory processes. However, limited studies have reported the involvement of PI3KC2γ in RA, and the underlying mechanism remains largely unknown. Therefore, we investigated the role of PI3KC2γ as a novel therapeutic target for RA and the effect of its s…
  • Molecular Mechanisms of Thyroid Hormone Transport by l-Type Amino Acid Transporter. [Journal Article]
    Exp Clin Endocrinol Diabetes 2019Krause G, Hinz KM
  • Thyroid hormones (TH) pass through the plasma membrane into the target cells via transporter proteins. Thyroid hormone transporters that have been identified until now belong to two different solute carrier (SLC) subfamilies i) the major facilitator superfamily (MFS) and ii) the amino acid polyamine-organocation (APC) superfamily. Both are comprised by 12 transmembrane helices, however with diffe…
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