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314 results
  • The effect of anti-emetic drugs on rat embryonic heart activity. [Journal Article]
    Reprod Toxicol 2019; 87:140-145Ritchie HE, Huss IB, Webster WS
  • Nausea and vomiting of pregnancy (NVP) is the most common medical complaint during pregnancy affecting up to 70% of pregnant women worldwide. Some antiemetic medications (AEM) (droperidol, domperidone, granisetron, metoclopramide and trifluoperazine) used to treat NVP have the unwanted side effect of hERG blockade. The hERG potassium channel is essential for normal heart rhythm in both the adult …
  • A somnolent woman in her fifties with acute circulatory failure. [Journal Article]
    Tidsskr Nor Laegeforen 2019; 139(9)Viland J, Langørgen J, Wendelbo Ø
  • CONCLUSIONS: Flecainide blocks sodium channels in cardiomyocytes. Intoxication with flecainide is rare, with mortality rates of about 10 %. Sodium bicarbonate in larger doses has been reported to stabilise patients with flecainide intoxication due to modification of the binding of flecainide to sodium receptors in cardiomyocytes, and due to alkalisation which makes flecainide detach from sodium receptors. Our patient had a temporary effect with narrowing of QRS complexes after receiving sodium bicarbonate. She also showed a beneficial effect from implantation of a temporary pacemaker, although earlier case reports have described problems with high thresholds and capture failure.
  • Women's perspectives on the management and consequences of hyperemesis gravidarum - a descriptive interview study. [Journal Article]
    Scand J Prim Health Care 2019; 37(1):30-40Havnen GC, Truong MB, … Nordeng H
  • CONCLUSIONS: Despite the high psychosocial burden and major impact on daily activities, many women with HG reported a lack of support from healthcare professionals and suboptimal management. Greater awareness and knowledge among healthcare professionals is needed to improve care for women with HG. Key Points There is a paucity of studies on management and the consequences of HG on women's daily lives and psychosocial burden. We found that: • Many women described HG as one of their worst life experiences with profound morbidity. • Many women reported suboptimal management of HG and lack of support from healthcare professionals. • Greater understanding of patient perspectives among healthcare professionals is important to improve care and management for HG patients.
  • Drugs and Lactation Database (LactMed): Meclizine [BOOK]
    National Library of Medicine (US): Bethesda (MD)BOOK
  • Occasional doses of meclizine are probably acceptable during breastfeeding. Large doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established.
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