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Unbound Medicine.
(meclizine hydrochloride)
328 results
  • The effects of meclizine on motion sickness revisited. [Journal Article]
    Br J Clin Pharmacol. 2020 Feb 19 [Online ahead of print]Wibble T, Engström J, … Pansell T
  • CONCLUSIONS: Meclizine had an inhibitory effect on eye movement reflexes for low accelerations during VIS+VES trials. This indicates that meclizine may not primarily work through sensory-specific mechanisms, but rather on a more central level. Practically, meclizine shows promise in targeting motion-sickness evoked by everyday activities, but its use may be counterproductive in high-acceleration environments.
  • Vestibular Migraine: Treatment and Prognosis. [Journal Article]
    Semin Neurol. 2020 Feb; 40(1):83-86.von Brevern M, Lempert T
  • Treatment of vestibular migraine currently lacks a firm scientific basis, as high quality randomized controlled trials are not available. Therefore, recommendations are largely borrowed from the migraine sphere. The first therapeutic step is explanation and reassurance. Many patients do not need pharmacological treatment, as attacks may be infrequent and tolerable. Acute attacks can be ameliorate…
  • Enantiomeric Separation of Meclizine Hydrochloride in Pharmaceutical Dosage Form by HPLC method. [Journal Article]
    Curr Drug Res Rev. 2019 Dec 11 [Online ahead of print]Gowramma B, Kumar RS, … Meyyanathan SN
  • A basic, powerful and isocratic chiral fluid chromatographic technique was created and approved for the enantiomeric partition of meclizine hydrochloride in pharmaceutical dose structure. The chromatographic partition was accomplished on Phenomenex® Lux Cellulose 1 (250 mm x 4.6 mm i.d, 5 µm molecule size) section utilizing portable stage framework containing acetonitrile: 25mM ammonium bicarbona…
  • A Medical Review of Fatal High-G U.S. Aerobatic Accidents. [Journal Article]
    Aerosp Med Hum Perform. 2019 Nov 01; 90(11):959-965.Mills WD, Greenhaw RM, Wang JMP
  • INTRODUCTION: Exposure to high G force is a known safety hazard in military aviation as well as civilian aerobatic flight. Tolerance to high G forces has been well studied in military pilots, but there is little research directed at civilian pilots who may have medications or medical conditions not permitted in military pilots.METHODS: In this case-control study, we identified 89 fatal high-G a…
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Antiemetic Agents [BOOK]
    . National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • Antiemetics are used for the symptomatic management of nausea and vomiting that can be caused by a variety of medical conditions and situations, including acute gastroenteritis, pregnancy, surgery, anesthesia, opioids and chemotherapy. Antiemetics are rare causes of liver injury, partially because they are used in low doses and for a short time only. Antiemetics can be categorized based upon thei…
  • The effect of anti-emetic drugs on rat embryonic heart activity. [Journal Article]
    Reprod Toxicol. 2019 08; 87:140-145.Ritchie HE, Huss IB, Webster WS
  • Nausea and vomiting of pregnancy (NVP) is the most common medical complaint during pregnancy affecting up to 70% of pregnant women worldwide. Some antiemetic medications (AEM) (droperidol, domperidone, granisetron, metoclopramide and trifluoperazine) used to treat NVP have the unwanted side effect of hERG blockade. The hERG potassium channel is essential for normal heart rhythm in both the adult …
  • A somnolent woman in her fifties with acute circulatory failure. [Case Reports]
    Tidsskr Nor Laegeforen. 2019 May 28; 139(9)Viland J, Langørgen J, Wendelbo Ø
  • CONCLUSIONS: Flecainide blocks sodium channels in cardiomyocytes. Intoxication with flecainide is rare, with mortality rates of about 10 %. Sodium bicarbonate in larger doses has been reported to stabilise patients with flecainide intoxication due to modification of the binding of flecainide to sodium receptors in cardiomyocytes, and due to alkalisation which makes flecainide detach from sodium receptors. Our patient had a temporary effect with narrowing of QRS complexes after receiving sodium bicarbonate. She also showed a beneficial effect from implantation of a temporary pacemaker, although earlier case reports have described problems with high thresholds and capture failure.
  • Antileishmanial activity of H1-antihistamine drugs and cellular alterations in Leishmania (L.) infantum. [Journal Article]
    Acta Trop. 2019 Jul; Melo Mendes V, Tempone AG, Treiger Borborema SE
  • Leishmaniases are infectious diseases caused by protozoan parasites Leishmania and transmitted by sand flies. Drug repurposing is a therapeutic approach that has shown satisfactory results in their treatment. Analyses of antihistaminic drugs have revealed their in vitro and in vivo activity against trypanosomatids. In this way, this study evaluated the antileishmanial activity of H1-antihistamine…
  • Women's perspectives on the management and consequences of hyperemesis gravidarum - a descriptive interview study. [Journal Article]
    Scand J Prim Health Care. 2019 Mar; 37(1):30-40.Havnen GC, Truong MB, … Nordeng H
  • CONCLUSIONS: Despite the high psychosocial burden and major impact on daily activities, many women with HG reported a lack of support from healthcare professionals and suboptimal management. Greater awareness and knowledge among healthcare professionals is needed to improve care for women with HG. Key Points There is a paucity of studies on management and the consequences of HG on women's daily lives and psychosocial burden. We found that: • Many women described HG as one of their worst life experiences with profound morbidity. • Many women reported suboptimal management of HG and lack of support from healthcare professionals. • Greater understanding of patient perspectives among healthcare professionals is important to improve care and management for HG patients.
  • Drugs and Lactation Database (LactMed): Meclizine [BOOK]
    . National Library of Medicine (US): Bethesda (MD)BOOK
  • Occasional doses of meclizine are probably acceptable during breastfeeding. Large doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established.
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