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11,951 results
  • Immune thrombocytopenia (ITP): Pathophysiology update and diagnostic dilemmas. [Review]
    Vet Clin Pathol 2019LeVine DN, Brooks MB
  • Immune thrombocytopenia (ITP) is a common autoimmune bleeding disorder. The understanding of ITP pathogenesis is rapidly evolving. We now recognize ITP as a complex and heterogeneous syndrome that results from a combination of humoral and cell-mediated attacks on platelets peripherally and megakaryocytes in the bone marrow. Autoantibody-mediated ITP also varies in the pathway used to clear platel…
  • Genetic platelet depletion is superior in platelet transfusion compared to current models. [Journal Article]
    Haematologica 2019Salzmann M, Schrottmaier WC, … Assinger A
  • Genetically modified mice advanced our knowledge on platelets in hemostasis and beyond tremendously. However, mouse models harbor certain limitations, including availability of platelet specific transgenic strains, and off-target effects on other cell types. Transfusion of genetically modified platelets into thrombocytopenic mice circumvents these problems. Additionally, ex vivo treatment of plat…
  • Human induced pluripotent stem cell-derived blood products: state of the art and future directions. [Review]
    FEBS Lett 2019Hansen M, von Lindern M, … Varga E
  • In vitro cultured blood cells for transfusion purposes provide a safe alternative to donor blood, particularly for patients that require recurrent transfusions, and can be used as carriers of therapeutic molecules. In vitro derivation of hematopoietic cell types from human induced pluripotent stem cells (iPSCs) allows for a constant, well defined production pipeline for such advanced therapeutic …
  • Megakaryocytes participate in the occurrence of bleomycin-induced pulmonary fibrosis. [Journal Article]
    Cell Death Dis 2019; 10(9):648Zhou Y, Zhang B, … Luo Z
  • Pulmonary fibrosis is characterized by the remodeling of fibrotic tissue and collagen deposition, which mainly results from aberrant fibroblasts proliferation and trans-differentiation to myofibroblasts. Patients with chronic myelogenous leukemia, myeloproliferative disorder, and scleroderma with pulmonary fibrosis complications show megakaryocyte infiltration in the lung. In this study, we demon…
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