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129,173 results
  • TRPing the homeostatic alarm - Melanoma cells are selectively vulnerable to TRPML1 deletion. [Journal Article]
    Cell Calcium 2019; 84:102082Jung J, Venkatachalam K
  • To thrive in otherwise inhospitable conditions, cancer cells utilize endolysosomes to impose homeostatic control over cellular metabolism and growth. In a recent study, Kasitinon et al. demonstrate a requirement for the endolysosomal channel, TRPML1, in proliferation and survival of melanoma cells. This study adds to a growing list of cancers that exhibit selective vulnerability to the loss of TR…
  • Dense pooling layers in fully convolutional network for skin lesion segmentation. [Journal Article]
    Comput Med Imaging Graph 2019; 78:101658Nasr-Esfahani E, Rafiei S, … Reza Soroushmehr SM
  • One of the essential tasks in medical image analysis is segmentation and accurate detection of borders. Lesion segmentation in skin images is an essential step in the computerized detection of skin cancer. However, many of the state-of-the-art segmentation methods have deficiencies in their border detection phase. In this paper, a new class of fully convolutional network is proposed, with new den…
  • Immunohistochemistry for PRAME in the Distinction of Nodal Nevi From Metastatic Melanoma. [Journal Article]
    Am J Surg Pathol 2019Lezcano C, Pulitzer M, … Busam KJ
  • The distinction of metastatic melanoma from melanocytic nevi in lymph nodes can on occasion be difficult. As diffuse immunohistochemical (IHC) PRAME (PReferentially expressed Antigen in MElanoma) expression is detected in the majority of primary and metastatic melanomas, but rarely in nevi, we reasoned that PRAME could be a useful adjunct marker for the diagnosis of melanocytes in lymph nodes. In…
  • Cytotoxic and apoptotic potential of Phyllodium elegans extracts on human cancer cell lines. [Journal Article]
    Bioengineered 2019Jung S, Shin J, … Oh JW
  • The extract of Phyllodium (P.) elegans was investigated for its anti-cancer properties on brain astroglioma cells (U251-MG), colorectal carcinoma cells (HCT116), and malignant melanoma cells (A375). P. elegans methanolic extract (PeME) showed cytotoxicity on all three cancer cell lines tested. The cell viability assay revealed that PeME significantly reduced the viability of these cells. Clear ap…
  • Mechanisms of Innate Immune Activation by a Hybrid Alphavirus-Rhabdovirus Vaccine Platform. [Journal Article]
    J Interferon Cytokine Res 2019Marchese AM, Chiale C, … Robek MD
  • Virus-like vesicles (VLV) are infectious, self-propagating alphavirus-vesiculovirus hybrid vaccine vectors that can be engineered to express foreign antigens to elicit a protective immune response. VLV are highly immunogenic and nonpathogenic in vivo, and we hypothesize that the unique replication and structural characteristics of VLV efficiently induce an innate antiviral response that enhances …
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