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(menadiol sodium diphosphate)
15 results
  • A pharmacokinetic study with the high-dose anticancer agent menadione in rabbits. [Journal Article]
    Biopharm Drug Dispos 1996; 17(6):493-9Hu OY, Wu CY, … Whang-Peng J
  • The aim of this investigation was to assess the pharmacokinetic properties of high-dose menadione (VK3), as an anticancer agent, in plasma and red blood cells (RBCs) in rabbits. An extremely high dose of 75 mg menadiol sodium diphosphate (Synkayvite) was intravenously injected. HPLC analysis was applied to measure the major metabolite, menadione, VK3. The kinetic properties of VK3 in both plasma …
  • Hepatitis B-like infection in a Pacific white-sided dolphin (Lagenorhynchus obliquidens). [Case Reports]
    J Am Vet Med Assoc 1990; 196(1):127-30Bossart GD, Brawner TA, … Bradley P
  • A Pacific white-sided dolphin (Lagenorhynchus obliquidens) developed clinical signs, serum biochemical values, and serologic viral markers consistent with chronic persistent hepatitis caused by a hepatitis B-like virus. The hepatitis had a sporadic cyclical pattern of lethargy, inappetance, and icterus, with leukocytosis and increased serum activities of alanine transaminase, aspartate transamina…
  • Differential pulse polarographic determination of plasma menadione. [Journal Article]
    Anal Biochem 1984; 141(2):488-93Akman SA, Kusu F, … Block J
  • A differential pulse polarographic assay for plasma vitamin K3 (menadione) has been developed. Details of the assay are (i) lipid-soluble material is extracted from plasma into ether by the method of Bjornsson et al. [(1978) Thromb. Haemostas. 2, 466-473]; (ii) ether is evaporated under nitrogen and the residue is dissolved in the supporting electrolyte, methanol: 0.2 M borate buffer (9:1), pH 6.…
  • Drug therapy reviews: clinical use of hemostatic agents. [Journal Article]
    Am J Hosp Pharm 1978; 35(4):414-22Lowe GD, Lawson DH
  • Systemic hemostatic agents are reviewed. Among the agents discussed are vitamin K preparations (phytonadione, menadione, menadione sodium bisulfite, menadiol sodium diphosphate); and blood products (whole blood, plasma, cryoprecipitate, factor VIII concentrates, factor IX concentrates and fibrinogen concentrates). Normal and abnormal hemostasis and fibrinolysis are discussed, as is the general ma…
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