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3,788 results
  • Modern use of 5-aminosalicylic acid compounds for ulcerative colitis. [Journal Article]
    Expert Opin Biol Ther 2019; :1-16Le Berre C, Roda G, … Peyrin-Biroulet L
  • Introduction: For 30 years, 5-aminosalicylic acid (5-ASA) has been the backbone of therapeutic management in patients with ulcerative colitis (UC). In the biologic era, it still remains the treatment of choice in mild-to-moderate UC. Positioning of this therapeutic class in moderate-to-severe UC is less clear. Areas covered: Several studies demonstrated the ability of 5-ASA to induce endoscopic r…
  • Maneuvering Clinical Pathways for Ulcerative Colitis. [Review]
    Curr Gastroenterol Rep 2019; 21(10):52Johnson CM, Linzay CD, Dassopoulos T
  • Recent years have brought about several advances in the treatment of patients with ulcerative colitis (UC). Here, we discuss salient recommendations of recent treatment guidelines; review the efficacy, safety, and real-world data of vedolizumab and tofacitinib; appraise their place vis-à-vis established agents; and consider the newly proposed approaches of risk-stratified and treat-to-target ther…
  • The effects of di-butyl phthalate exposure from medications on human sperm RNA among men. [Journal Article]
    Sci Rep 2019; 9(1):12397Estill M, Hauser R, … Krawetz SA
  • Endocrine disruptors, such as phthalates, are suspected of affecting reproductive function. The Mesalamine and Reproductive Health Study (MARS) was designed to address the physiological effect of in vivo phthalate exposure on male reproduction in patients with Inflammatory Bowel Disease (IBD). As part of this effort, the effect on sperm RNAs to DBP exposure were longitudinally assessed using a cr…
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