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220 results
  • StatPearls: Antipsychotic Medications [BOOK]
    StatPearls Publishing: Treasure Island (FL) Chokhawala Krutika K Stevens Lee L Louisiana State Un Hospital BOOK
  • First-generation antipsychotics are dopamine receptor antagonists (DRA) and are known as typical antipsychotics. They include phenothiazines (trifluoperazine, perphenazine, prochlorperazine, acetophenazine, triflupromazine, mesoridazine), butyrophenones (Haloperidol), thioxanthenes (thiothixene, chlorprothixene), dibenzoxazepines (loxapine), dihydroindole (molindone), and diphenylbutylpiperidines…
  • A subset of N-substituted phenothiazines inhibits NADPH oxidases. [Journal Article]
    Free Radic Biol Med 2015; 86:239-49Seredenina T, Chiriano G, … Jaquet V
  • NADPH oxidases (NOXs) constitute a family of enzymes generating reactive oxygen species (ROS) and are increasingly recognized as interesting drug targets. Here we investigated the effects of 10 phenothiazine compounds on NOX activity using an extensive panel of assays to measure production of ROS (Amplex red, WST-1, MCLA) and oxygen consumption. Striking differences between highly similar phenoth…
  • Haloperidol versus first-generation antipsychotics for the treatment of schizophrenia and other psychotic disorders. [Review]
    Cochrane Database Syst Rev 2015; 1:CD009831Dold M, Samara MT, … Leucht S
  • CONCLUSIONS: The findings of the meta-analytic calculations support the statements of previous narrative, unsystematic reviews suggesting comparable efficacy of first-generation antipsychotics. In efficacy-related outcomes, there was no clear evidence of a difference between the prototypal drug haloperidol and other, mainly high-potency first-generation antipsychotics. Additionally, we demonstrated that haloperidol is characterised by a similar risk profile compared to the other first-generation antipsychotic compounds. The only statistically significant difference in specific side effects was that haloperidol produced less akathisia in the medium term. The results were limited by the low methodological quality in many of the included original studies. Data for the main results were low or very low quality. Therefore, future clinical trials with high methodological quality are required.
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