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362,214 results
  • Respiratory syncytial virus tropism for olfactory sensory neurons in mice. [Journal Article]
    J Neurochem 2019; :e14936Bryche B, Frétaud M, … Meunier N
  • The olfactory mucosa, where the first step of odor detection occurs, is a privileged pathway for environmental toxicants and pathogens towards the central nervous system. Indeed, some pathogens can infect olfactory sensory neurons including their axons projecting to the olfactory bulb allowing them to bypass the blood-brain barrier and reach the central nervous system (CNS) through the so-called …
  • Engineered E. coli Nissle 1917 for the delivery of matrix-tethered therapeutic domains to the gut. [Journal Article]
    Nat Commun 2019; 10(1):5580Praveschotinunt P, Duraj-Thatte AM, … Joshi NS
  • Mucosal healing plays a critical role in combatting the effects of inflammatory bowel disease, fistulae and ulcers. While most treatments for such diseases focus on systemically delivered anti-inflammatory drugs, often leading to detrimental side effects, mucosal healing agents that target the gut epithelium are underexplored. We genetically engineer Escherichia coli Nissle 1917 (EcN) to create f…
  • T cell-derived interferon-γ programs stem cell death in immune-mediated intestinal damage. [Journal Article]
    Sci Immunol 2019; 4(42)Takashima S, Martin ML, … Hanash AM
  • Despite the importance of intestinal stem cells (ISCs) for epithelial maintenance, there is limited understanding of how immune-mediated damage affects ISCs and their niche. We found that stem cell compartment injury is a shared feature of both alloreactive and autoreactive intestinal immunopathology, reducing ISCs and impairing their recovery in T cell-mediated injury models. Although imaging re…
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