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19,855 results
  • Mechanism of Metformin on LPS-Induced Bacterial Myocarditis. [Journal Article]
  • DRDose Response 2019 Apr-Jun; 17(2):1559325819847409
  • Li M, Gou Y, … Sun W
  • CONCLUSIONS: We demonstrate that LPS stimulation may activate intracellular MAPK/JNK and NF-κB signaling pathways and thus induce cell apoptosis. In contrast, metformin reduced apoptosis by inhibiting this signaling pathway and increasing the expression level of Bcl-2. Moreover, it was found that metformin could enhance the ability of cells to antagonize redox damage by regulating the activities of superoxide dismutase and lactate dehydrogenase and subsequently promote the recovery of cardiomyocyte function.
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