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44 results
  • Monoamine oxidase A inhibition by toxic concentrations of metaxalone. [Journal Article]
    Clin Toxicol (Phila) 2019; :1-5Cherrington B, Englich U, … Hodgman M
  • CONCLUSIONS: Our in vitro model shows that at toxic concentrations similar to those reported in case reports metaxalone shows significant MAO-A inhibition. Clinicians should be aware of this mechanism and understand the potentially lethal interactions metaxalone can have when prescribed with other serotonergic drugs and consider this as a potential cause of serotonin toxicity, especially in overdose scenarios.
  • Inhibition of In Vitro Metabolism of Opioids by Skeletal Muscle Relaxants. [Journal Article]
    Basic Clin Pharmacol Toxicol 2018; 123(3):327-334Moody DE, Fu Y, Fang WB
  • The purpose of this study was to test the hypothesis that skeletal muscle relaxants could inhibit the in vitro metabolism of common comedications opioids buprenorphine, methadone and oxycodone. The compounds [solubility-limited concentration (μM) studied] were as follows: baclofen (1000), carisoprodol (200), its metabolite meprobamate (1000), chlorzoxazone (200), cyclobenzaprine (1000), metaxalon…
  • Postmortem Metaxalone (Skelaxin®) Data from North Carolina. [Journal Article]
    J Anal Toxicol 2015; 39(8):629-36Bishop-Freeman SC, Miller A, … Winecker RE
  • The North Carolina Office of the Chief Medical Examiner Toxicology Laboratory identified 61 cases from 2002 to 2014 where metaxalone was detected during routine postmortem drug screening in support of a determination of cause and manner of death. Decedents were divided into groups based on the manner of death with the goal of studying metaxalone concentrations in overdose and non-overdose situati…
  • A rare fatality attributed solely to metaxalone. [Case Reports]
    J Anal Toxicol 2015; 39(4):321-3Curtis B, Jenkins C, Wiens AL
  • Metaxalone (Skelaxin) is a prescription medication used primarily as a centrally acting skeletal muscle relaxer and is rarely implicated in drug fatalities. We present a case study involving a relatively young decedent where metaxalone is implicated as the sole agent causing death with little in the way of confounding factors. The concentration of metaxalone in hospital admission blood was determ…
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