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(methimazole)
4,553 results
  • Timing, prevalence, and dynamics of thyroid disorders in children and adolescents affected with Down syndrome. [Journal Article]
    J Pediatr Endocrinol Metab. 2020 Jul 11 [Online ahead of print]Calcaterra V, Crivicich E, … Larizza D
  • Objectives Limited data on the evolution of thyroid disorders (TD) in Down syndrome (DS) are available. We characterized the timing, prevalence, and dynamics of TD in patients with DS during a long-term follow-up. Methods We retrospectively evaluated 91 children and adolescents with DS (12.5 ± 8.3; follow-up 7.5 ± 6.2). Children were monitored at birth, 6, and 12 months of age and twice a year th…
  • A rare case of thyrotoxicosis and bilateral internal carotid artery dissections. [Case Reports]
    Am J Emerg Med. 2020 Jun 27 [Online ahead of print]Winter T, Kraut E, Thompson K
  • Cervical artery dissection is a rare but important diagnosis to consider in young patients presenting with stroke. Multiple etiologies of cervical artery dissections have been previously reported, but the association with thyrotoxicosis is extremely rare. A previously healthy 43-year-old female presented to the emergency department with new symptoms related to thyrotoxicosis and bilateral interna…
  • Graves' hyperthyroidism-related pancytopenia: a case report with literature review. [Review]
    Hormones (Athens). 2020 Jul 08 [Online ahead of print]Scappaticcio L, Bellastella G, … Rizzo MR
  • CONCLUSIONS: Searching in the English literature for previous studies, we identified only 30 cases worldwide to form our database. A demographic as well as clinical, laboratory, and histopathological analysis was performed. In most cases, the recovery of biochemical euthyroidism through the use of ATDs induced the resolution of pancytopenia (at laboratory and histological levels). Our review provides clinical, laboratory, and histopathological features of Graves's hyperthyroidism-related pancytopenia with a view to improving the knowledge of this rare hematological complication and assisting in the decision-making process regarding therapeutic options.
  • Sepsis and thyroid storm in a patient with methimazole-induced agranulocytosis. [Journal Article]
    BMJ Case Rep. 2020 Jul 06; 13(7)Nagarajan VD, Morales A, … Shenoi A
  • Paediatric hyperthyroidism cases are mostly caused by Grave's disease. Thyroid storm is a life-threatening condition seen rarely, in severe thyrotoxicosis, occurring in about 1%-2% of patients with hyperthyroidism. Antithyroid medications and beta-blockers are typically the first-line management of thyroid storm. We report a challenging case of a 15-year-old girl who presented with thyroid storm …
  • Antithyroid drugs and birth defects. [Review]
    Thyroid Res. 2020; 13:11.Andersen SL, Andersen S
  • Antithyroid drugs (ATDs) are preferred for the treatment of hyperthyroidism caused by Graves' disease in pregnant women. The drugs have been a recognized treatment for decades, and a general risk of side effects is known. For the use of ATDs in pregnancy, a concern about teratogenic side effects has been brought forward since the 1970s. In more recent years, a number of large observational studie…
  • Dome-and-dart T Waves and Hyperthyroidism - A Case Report. [Case Reports]
    Eur Endocrinol. 2020 Apr; 16(1):69-71.Parolin M, Dassie F, … Maffei P
  • We briefly describe a case of a 31-year-old man with persistent hyperthyroidism, despite medical treatment with high dose methimazole. Twelve-lead 24-hour Holter monitoring showed bifid (or dome-and-dart) T waves and echocardiography revealed mild left ventricle dilatation. Hyperthyroidism was eventually treated with total thyroidectomy, and thereafter, T waves became normal and the left ventricl…
  • Platelet function in cats with hyperthyroidism. [Journal Article]
    J Feline Med Surg. 2020 May 21 [Online ahead of print]Hiebert EC, Panciera DL, … Bartl L
  • CONCLUSIONS: Platelet function, as measured by closure time under high shear conditions using C-ADP as an agonist, was not affected by hyperthyroidism in this group of cats. Further research is needed to determine if a hypercoagulable state exists in hyperthyroid cats and the potential roles platelets and von Willebrand factor may have.
  • Thyrotoxic Periodic Paralysis With Features of Andersen-Tawil Syndrome: A Case Report and Literature Review. [Case Reports]
    Cureus. 2020 May 17; 12(5):e8169.Iskander B, Malik BH, Cancarevic I
  • Thyrotoxic periodic paralysis (TPP) is a rare manifestation of hyperthyroidism. The pathophysiology of hyperthyroidism causing periodic paralysis involves the Na+/K+ ATPase and potassium channels. We present a case of a 30-year-old male who presented to the ED with acute onset of upper and lower limb weakness. The patient was found to have bilateral weakness in the upper and lower limbs, orbital …
  • Methimazole Inhibits the Expression of GFAP and the Migration of Astrocyte in Scratched Wound Model In Vitro. [Journal Article]
    Mediators Inflamm. 2020; 2020:4027470.Zhao L, Zhang X, Zhang C
  • Astrocytes respond to central nervous system (CNS) insults with varieties of changes, such as cellular hypertrophy, migration, proliferation, scar formation, and upregulation of glial fibrillary acidic protein (GFAP) expression. While scar formation plays a very important role in wound healing and prevents further bleeding by forming a physical barrier, it is also one of key features of CNS injur…
  • Effects of maternal hypothyroidism in the gastrointestinal system of male young offspring from Wistar rats. [Journal Article]
    J Dev Orig Health Dis. 2020 Apr 29 [Online ahead of print]de Rezende LP, Fortunato Silva J, … Balbi APC
  • Alterations in the maternal environment may impact on the fetal development. The objective of this study was to investigate the gastrointestinal consequences of maternal hypothyroidism for the male offspring from Wistar rats. The pregnant rats were divided into three groups: control (C - received water), experimental 1 [E1 - received methimazole (MMI) solution] during gestation and lactation, and…
  • 109 Hyperthyroidism-induced Psychosis. [Journal Article]
    CNS Spectr. 2020 Apr; 25(2):270-271.Shaikh A, Shah K, Idowu J
  • CONCLUSIONS: Psychosis associated with thyroid nodule is rare but possible. The onset of psychotic syndrome is an important clinical element whose underlying medical cause must be promptly clarified. Psychosis can present in a number of ways and can have different causes. Apart from psychiatric causes, underlying medical causes should always be considered. In this case it was important to get a full clinical history of the patient as well as complete physical examination. The differential diagnosis of a psychotic disorder in light of a medical disease should always be considered in order to promptly diagnose and treat the underlying cause to reduce the morbidity and possibly the mortality associated with it.
  • Effect of Thyroperoxidase and Deiodinase Inhibition on Anterior Swim Bladder Inflation in the Zebrafish. [Journal Article]
    Environ Sci Technol. 2020 May 19; 54(10):6213-6223.Stinckens E, Vergauwen L, … Knapen D
  • A set of adverse outcome pathways (AOPs) linking inhibition of thyroperoxidase and deiodinase to impaired swim bladder inflation in fish has recently been developed. These AOPs help to establish links between these thyroid hormone (TH) disrupting molecular events and adverse outcomes relevant to aquatic ecological risk assessment. Until now, very little data on the effects of TH disruption on inf…
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