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830 results
  • Characterization of binding of antipsychotics to muscarinic receptors using mouse cerebral cortex. [Journal Article]
    J Pharmacol Sci 2019; 140(2):197-200Obara K, Horiguchi S, … Tanaka Y
  • Antipsychotics are often the first-line treatment for behavioral and psychological symptoms of dementia. However, the potential anticholinergic effects of antipsychotics could counteract the therapeutic effects of cholinesterase inhibitors used to treat dementia. We investigated the inhibitory effects of 26 antipsychotics on [N-Methyl-3H]scopolamine specific binding in mouse cerebral cortex. At 1…
  • Theoretical study on the metabolic mechanisms of levmepromazine by cytochrome P450. [Journal Article]
    J Mol Model 2016; 22(10):237Wang Y, Chen Q, … Xue Y
  • Levomepromazine, an "older" typical neuroleptic, is widely applied in psychiatry for the treatment of schizophrenia. The biotransformation of Levomepromazine remains elusive up to now, but found to result in the formation of different derivatives that may contribute to the therapeutic and/or side-effects of the parent drug. The present work aims to resolve the metabolic details of Levomepromazine…
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