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4,684 results
  • TET methylcytosine oxidases: new insights from a decade of research. [Journal Article]
    J Biosci 2020; 45Lio CJ, Yue X, … Rao A
  • In mammals, DNA methyltransferases transfer a methyl group from S-adenosylmethionine to the 5 position of cytosine in DNA. The product of this reaction, 5-methylcytosine (5mC), has many roles, particularly in suppressing transposable and repeat elements in DNA. Moreover, in many cellular systems, cell lineage specification is accompanied by DNA demethylation at the promoters of genes expressed at…
  • Age-Associated TET2 Mutations: Common Drivers of Myeloid Dysfunction, Cancer and Cardiovascular Disease. [Review]
    Int J Mol Sci 2020; 21(2)Ferrone CK, Blydt-Hansen M, Rauh MJ
  • Acquired, inactivating mutations in Tet methylcytosine dioxygenase 2 (TET2) are detected in peripheral blood cells of a remarkable 5%-10% of adults greater than 65 years of age. They impart a hematopoietic stem cell advantage and resultant clonal hematopoiesis of indeterminate potential (CHIP) with skewed myelomonocytic differentiation. CHIP is associated with an overall increased risk of transfo…
  • miR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2. [Journal Article]
    JCI Insight 2020; 5(1)Fuentes-Mattei E, Bayraktar R, … Redis RS
  • Myelofibrosis (MF) is a myeloproliferative neoplasm characterized by cytopenia and extramedullary hematopoiesis, resulting in splenomegaly. Multiple pathological mechanisms (e.g., circulating cytokines and genetic alterations, such as JAKV617F mutation) have been implicated in the etiology of MF, but the molecular mechanism causing resistance to JAK2V617F inhibitor therapy remains unknown. Among …
  • The roles of TET family proteins in development and stem cells. [Review]
    Development 2020; 147(2)Yang J, Bashkenova N, … Wang J
  • Ten-eleven translocation (TET) methylcytosine dioxygenases are enzymes that catalyze the demethylation of 5-methylcytosine on DNA. Through global and site-specific demethylation, they regulate cell fate decisions during development and in embryonic stem cells by maintaining pluripotency or by regulating differentiation. In this Primer, we provide an updated overview of TET functions in developmen…
  • Delineation of a Human Mendelian Disorder of the DNA Demethylation Machinery: TET3 Deficiency. [Journal Article]
    Am J Hum Genet 2020Beck DB, Petracovici A, … Fahrner JA
  • Germline pathogenic variants in chromatin-modifying enzymes are a common cause of pediatric developmental disorders. These enzymes catalyze reactions that regulate epigenetic inheritance via histone post-translational modifications and DNA methylation. Cytosine methylation (5-methylcytosine [5mC]) of DNA is the quintessential epigenetic mark, yet no human Mendelian disorder of DNA demethylation h…
  • Evidence for novel epigenetic marks within plants. [Journal Article]
    AIMS Genet 2019; 6(4):70-87Mahmood AM, Dunwell JM
  • Variation in patterns of gene expression can result from modifications in the genome that occur without a change in the sequence of the DNA; such modifications include methylation of cytosine to generate 5-methylcytosine (5mC) resulting in the generation of heritable epimutation and novel epialleles. This type of non-sequence variation is called epigenetics. The enzymes responsible for generation…
  • eRice: a refined epigenomic platform for japonica and indica rice. [Journal Article]
    Plant Biotechnol J 2020Zhang P, Wang Y, … Gu X
  • Epigenetic modifications including chromatin modifications and DNA methylation have emerged as essential marks that can influence various biological pathways in multicellular organisms. In plants, DNA methylation such as 5-methylcytosine (5mC) and N6-methyladenosine (6mA), which was discovered later, have crucial roles in the regulation of developmental cues and responses to environmental stresse…
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