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6,818 results
  • Isoniazid-Induced Systemic Lupus Erythematosus: A Case Report. [Journal Article]
    Drug Saf Case Rep 2019; 6(1):7Vaghela JH, Solanki Y, … Purohit B
  • Systemic lupus erythematosus (SLE) can be induced by various medications, such as hydralazine, procainamide, isoniazid, methyldopa, chlorpromazine, quinidine, and minocycline. A patient was admitted complaining of fever with chills and rigor. After being diagnosed with tuberculous meningitis, the patient was given antituberculosis treatment. As the patient did not improve, detailed investigations…
  • Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance. [Journal Article]
    Nat Commun 2019; 10(1):2767Agudelo LZ, Ferreira DMS, … Ruas JL
  • The coactivator PGC-1α1 is activated by exercise training in skeletal muscle and promotes fatigue-resistance. In exercised muscle, PGC-1α1 enhances the expression of kynurenine aminotransferases (Kats), which convert kynurenine into kynurenic acid. This reduces kynurenine-associated neurotoxicity and generates glutamate as a byproduct. Here, we show that PGC-1α1 elevates aspartate and glutamate l…
  • Acute parkinsonism as an unexpected consequence of pituitary adenoma resection: A case report. [Case Reports]
    Medicine (Baltimore) 2019; 98(17):e15261Ho PL, Chen YC, … Huang P
  • CONCLUSIONS: This case highlights an unexpected association between transsphenoidal resection of pituitary tumors and acute parkinsonism which is a treatable manifestation of EPM. Correction of hyponatremia following transsphenoidal pituitary resections should be preceded cautiously because even gradual correction of hyponatremia can produce myelinolysis.
  • Treatment and Prevention of Hypertensive Disorders During Pregnancy. [Review]
    Clin Perinatol 2019; 46(2):173-185Leavitt K, Običan S, Yankowitz J
  • This article reviews the pharmacology of the most commonly used antihypertensive medications during pregnancy; their mechanism of action; and the effects on the mother, the fetus, and lactation. Each class of antihypertensive pharmacologic agents have specific mechanisms of action by which they exert their antihypertensive effect. β-Adrenoreceptor antagonists block these receptors in the peripher…
  • Mechanistic Insights of Chemicals and Drugs as Risk Factors for Systemic Lupus Erythematosus. [Journal Article]
    Curr Med Chem 2019Pan Q, Guo Y, … Liu HF
  • Systemic lupus erythematosus (SLE) is a chronic and relapsing heterogenous autoimmune disease that primarily affects women of reproductive age. Genetic and environmental risk factors are involved in the pathogenesis of SLE, and susceptibility genes have recently been identified. However, as gene therapy is far from clinical application, further investigation of environmental risk factors could re…
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