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(methylnaltrexone)
416 results
  • The MOVEMENT Trial. [Journal Article]
  • JAJ Am Heart Assoc 2019 Jan 22; 8(2):e010152
  • Holm M, Tornvall P, … van der Linden J
  • Background Morphine administration is a strong predictor of delayed onset of action of orally administered ticagrelor in patients with ST-segment-elevation myocardial infarction, likely because of im…
  • Pharmacological Treatment of Opioid-Induced Constipation Is Effective but Choice of Endpoints Affects the Therapeutic Gain. [Review]
  • DDDig Dis Sci 2019; 64(1):39-49
  • Nusrat S, Syed T, … Bielefeldt K
  • CONCLUSIONS: While treatment of OIC with active drugs is more effective than placebo, the relative gain depends on the choice of endpoints. The commonly used time-dependent response definition is associated with the highest response rate but is of questionable relevance in a chronic disorder. The limited data do not clearly demonstrate a unique advantage of the peripherally restricted opioid antagonists, suggesting that treatment with often cheaper agents should be optimized before shifting to these novel expensive agents.
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