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32,989 results
  • Big data differential analysis of microglial cell responses in neurodegenerative diseases. [Journal Article]
    Anat Cell Biol 2019; 52(4):469-477Tabassum R, Jeong NY, Chung HJ
  • Microarray technology has become an indispensable tool for monitoring the levels of gene expression in a given organism through organization, analysis, interpretation, and utilization of biological sequences. Importantly, preliminary microarray gene expression differs from experimentally validated gene expression. Generally, microarray analysis of gene expression in microglial cells is used to id…
  • Mfn2 Ablation in the Adult Mouse Hippocampus and Cortex Causes Neuronal Death. [Journal Article]
    Cells 2020; 9(1)Han S, Nandy P, … Zhu X
  • It is believed that mitochondrial fragmentation cause mitochondrial dysfunction and neuronal deficits in Alzheimer's disease. We recently reported that constitutive knockout of the mitochondria fusion protein mitofusin2 (Mfn2) in the mouse brain causes mitochondrial fragmentation and neurodegeneration in the hippocampus and cortex. Here, we utilize an inducible mouse model to knock out Mfn2 (Mfn2…
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