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2,207 results
  • Clinically relevant drug interactions between statins and antidepressants. [Review]
    J Clin Pharm Ther 2019Palleria C, Roberti R, … Russo E
  • CONCLUSIONS: Pharmacodynamic (PD) drug-drug interactions (DDIs) are unlikely to occur as statins are highly selective inhibitors of HMG-CoA reductase with no relevant effect on other enzymes or receptor systems. Despite the numerous PK studies on individual drugs belonging to statins and antidepressant agents, only a few case reports regarding specific DDIs are present in the literature and no clinical studies have been performed. PK data allow to speculate on potential DDIs, comparing the metabolic pathways, intestinal and liver transporters and elimination routes. Overall, second-generation antidepressants, in particular citalopram, escitalopram, mirtazapine, reboxetine and venlafaxine, have weak inhibitory effects on various cytochrome (CYP) isozymes and seem to have a more advantageous DDIs profile in vivo. Conversely, nefazodone, fluoxetine, paroxetine and fluvoxamine influence considerably CYPs activity with potential effects on statins plasma levels, although pravastatin, pitavastatin and rosuvastatin are not susceptible to inhibition by any CYP. Albeit no studies have been performed on P-glycoprotein (P-gp), interactions of clinical relevance are unlikely.Although DDIs with antidepressants are potentially, but rarely clinically significant, the use of antidepressants with a more favourable drug interaction profile is advisable. An evaluation on DDIs between these drugs can be useful for future PK/PD studies on drug-drug interaction to provide clinicians with more data for appropriate multiple drug regimens.
  • Inhibition effects of some antidepressant drugs on pentose phosphate pathway enzymes. [Journal Article]
    Environ Toxicol Pharmacol 2019; 72:103244Özaslan MS, Balcı N, … Küfrevioğlu Öİ
  • The glucose metabolism in the pentose cycle is essential to the source of NADPH. Deficiency of these enzymes have been linked to depression and psychotic disorders. Depression is an increasingly prevalent mental disorder which may cause loss of labor. Antidepressant drugs are commonly employed in treatments of mood disorders and anxiety treatment. The purpose of this study is to investigate the e…
  • Nabilone for the Treatment of Post-Traumatic Stress Disorder: A Review of Clinical Effectiveness and Guidelines [BOOK]
    Canadian Agency for Drugs and Technologies in Health: Ottawa (ON) Cowling Tara T MacDougall Danielle D BOOK
  • Post-traumatic stress disorder (PTSD) is characterized by substantial psychological or physiological distress following exposure to trauma.1 According to the most recent Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), criteria for PTSD diagnosis includes either direct, or indirect (e.g., as a witness, or having learned that a close family member or friend has experie…
  • Clinical Pearls on Sleep Management in Atopic Dermatitis. [Journal Article]
    Dermatitis 2019 Sep/Oct; 30(5):287-293Hendricks AJ, Manivannan M, Shi VY
  • Multiple etiologies contribute to sleep disturbance in atopic dermatitis (AD) patients, including learned scratching behavior and increased monoamines, cutaneous blood flow, inflammatory cell activities, and cytokines, as well as decreased melatonin, anti-inflammatory cytokines, and skin barrier function. Insomnia impairs cognitive development in children with AD, leading to behavioral problems a…
  • Methamphetamine Use: A New Wave in the Opioid Crisis? [Journal Article]
    J Addict Nurs 2019 Jul/Sep; 30(3):219-223Fogger SA
  • The ongoing drug crisis in the United States continues to be headlined with numbers of deaths related to opioid overdose. Less known to the public and health care providers is the rise in methamphetamine use, often in conjunction with opioids or adulterated with fentanyl. An old practice with a new twist is the use of methamphetamine in conjunction with an opioid such as heroin.
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