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219,548 results
  • Immune metabolism in PD-1 blockade-based cancer immunotherapy. [Journal Article]
    Int Immunol. 2020 Jul 05 [Online ahead of print]Kumar A, Chamoto K
  • Energy metabolism plays an important role in proliferating cells. Recent reports indicate that metabolic regulation or metabolic products can control immune cell differentiation, fate and reactions. Cancer immunotherapy based on blockade of programmed cell death protein 1 (PD-1) has been used worldwide, but a significant fraction of patients remain unresponsive. Therefore, clarifying the mechanis…
  • In vitro effects of 635 nm photobiomodulation under hypoxia/reoxygenation culture conditions. [Journal Article]
    J Photochem Photobiol B. 2020 Jun 24; 209:111935.Chaudary S, Karner L, … Dungel P
  • Photobiomodulation (PBM), especially in the red wavelength range, has been demonstrated to be an effective treatment option for superficial and chronic wounds. However, ischemia and subsequent reperfusion can further challenge wound healing. Therefore, we investigated the effect of pulsed red LED light at 635 nm on cellular function in an in-vitro model of hypoxia/reoxygenation (H/R) challenge. M…
  • Metformin Preferentially Provides Neuroprotection Following Cardiac Ischemia/Reperfusion in Non-Diabetic Rats. [Journal Article]
    Biochim Biophys Acta Mol Basis Dis. 2020 Jul 01 [Online ahead of print]Benjanuwattra J, Apaijai N, … Chattipakorn SC
  • Following acute myocardial infarction, re-establishment of coronary perfusion aggravates further injuries in the heart and remote organs including the brain as a consequence of ischemia/reperfusion (I/R) injury. Since pretreatment with metformin attenuated both cardiac and cerebral I/R injury via AMP-activated protein kinase (AMPK) pathways, we hypothesized that metformin given after ischemia mit…
  • Structural insight into mitochondrial β-barrel outer membrane protein biogenesis. [Journal Article]
    Nat Commun. 2020 Jul 03; 11(1):3290.Diederichs KA, Ni X, … Buchanan SK
  • In mitochondria, β-barrel outer membrane proteins mediate protein import, metabolite transport, lipid transport, and biogenesis. The Sorting and Assembly Machinery (SAM) complex consists of three proteins that assemble as a 1:1:1 complex to fold β-barrel proteins and insert them into the mitochondrial outer membrane. We report cryoEM structures of the SAM complex from Myceliophthora thermophila, …
  • Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome. [Journal Article]
    Eur Respir Rev. 2020 Jun 30; 29(156)Robinson MJ, Krasnodembskaya AD
  • Acute respiratory distress syndrome (ARDS) remains a significant source of mortality in critically ill patients. Characterised by acute, widespread alveolar inflammation and pulmonary oedema, its pathophysiological heterogeneity has meant that targeted treatments have remained elusive. Metabolomic analysis has made initial steps in characterising the underlying metabolic derangements of ARDS as a…
  • A global view of the miRNA-mitophagy connexion. [Journal Article]
    Prog Mol Biol Transl Sci. 2020; 172:37-54.Strappazzon F
  • Mitochondria are highly dynamics organelles that provide the necessary energy for cellular functions. However, when they are dysfunctional, they can, by contrast, be very harmful for the cell. Mitophagy ensures their recycling and preserves cell performance. This mechanism is particularly important in neurons because they use a lot of energy. Failed mitophagy can thus affect the development of ne…
  • Autophagy in motor neuron diseases. [Journal Article]
    Prog Mol Biol Transl Sci. 2020; 172:157-202.Rodríguez-Muela N
  • Motor neuron diseases (MNDs) are a wide group of neurodegenerative disorders characterized by the degeneration of a specific neuronal type located in the central nervous system, the motor neuron (MN). There are two main types of MNs, spinal and cortical MNs and depending on the type of MND, one or both types are affected. Cortical MNs innervate spinal MNs and these control a variety of cellular t…
  • Drug repurposing: Discovery of troxipide analogs as potent antitumor agents. [Journal Article]
    Eur J Med Chem. 2020 Jun 26; 202:112471.Lu N, Huo JL, … Liu HM
  • Drug repurposing plays a vital role in the discovery of undescribed bioactivities in clinical drugs. Based on drug repurposing strategy, we for the first time reported a novel series of troxipide analogs and then evaluated their antiproliferative activity against MCF-7, PC3, MGC-803, and PC9 cancer cell lines and WPMY-1, most of which showed obvious selectivity toward PC-3 over the other three ca…
  • FABP7 upregulation induces a neurotoxic phenotype in astrocytes. [Journal Article]
    Glia. 2020 Jul 03 [Online ahead of print]Killoy KM, Harlan BA, … Vargas MR
  • Fatty acid binding proteins (FABPs) are key regulators of lipid metabolism, energy homeostasis, and inflammation. They participate in fatty acid metabolism by regulating their uptake, transport, and availability of ligands to nuclear receptors. In the adult brain, FABP7 is especially abundant in astrocytes that are rich in cytoplasmic granules originated from damaged mitochondria. Mitochondrial d…
  • LIPH promotes metastasis by enriching stem-like cells in triple-negative breast cancer. [Journal Article]
    J Cell Mol Med. 2020 Jul 02 [Online ahead of print]Zhang Y, Zhu X, … Liu C
  • Lipase member H (LIPH), a novel member of the triglyceride lipase family. The clinical implications of its expression in breast cancer are still unclear. Therefore, in this study, we investigated the associations between LIPH and the tumorigenic behaviours of 144 triple-negative breast cancer (TNBC) patients. The ratio and mammosphere-forming ability of CD44+/CD24- stem-like cells were tested. Th…
  • Cancer and Alzheimer's disease: intracellular pH scales the metabolic disorders. [Review]
    Biogerontology. 2020 Jul 02 [Online ahead of print]Schwartz L, Peres S, … da Veiga Moreira J
  • Alzheimer's disease (AD) and cancer have much in common than previously recognized. These pathologies share common risk factors (inflammation and aging), with similar epidemiological and biochemical features such as impaired mitochondria. Metabolic reprogramming occurs during aging and inflammation. We assume that inflammation is directly responsible of the Warburg effect in cancer cells, with a …
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