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129,335 results
  • Multiple cytokine analyses of aqueous humor from the patients with retinitis pigmentosa. [Journal Article]
    Cytokine 2019; 127:154943Lu B, Yin H, … Yao K
  • CONCLUSIONS: Significantly increased levels of PDGF-AA, MMP2, MMP3, MMP-7, MMP-8, PAI-1, and TSP-2 and lower levels of BMP-4 were found in the aqueous humor of RP patients. This result indicates a disturbance of the extracellular matrix (ECM) and cytokines in RP patients and suggests a possible role of these cytokines in the pathogenesis of capsular contraction syndrome (CCS) in RP patients.
  • Machine Learning to Detect Alzheimer's Disease from Circulating Non-coding RNAs. [Journal Article]
    Genomics Proteomics Bioinformatics 2019Ludwig N, Fehlmann T, … Keller A
  • Blood-borne small non-coding (sncRNAs) are among the prominent candidates for blood-based diagnostic tests. Often, high-throughput approaches are applied to discover biomarker signatures. These have to be validated in larger cohorts and evaluated by adequate statistical learning approaches. Previously, we published high-throughput sequencing based microRNA (miRNA) signatures in Alzheimer's diseas…
  • Monocytes Prime Autoreactive T cells After Myocardial Infarction. [Journal Article]
    Am J Physiol Heart Circ Physiol 2019DeBerge MP, Yu S, … Thorp EB
  • In humans, loss of central tolerance for the cardiac self-antigen, α-myosin heavy chain (αMyHC), leads to circulation of cardiac autoreactive T cells and renders the heart susceptible to autoimmune attack after acute myocardial infarction (MI). MI triggers profound tissue damage, releasing danger signals and self-antigen by necrotic cardiomyocytes, which leads to recruitment of inflammatory monoc…
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