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82,782 results
  • Glia: victims or villains of the aging brain? [Review]
    Neurobiol Dis. 2020 Jul 02 [Online ahead of print]Salas IH, Burgado J, Allen NJ
  • Aging is the strongest risk factor for metabolic, vascular and neurodegenerative diseases. Aging alone is associated with a gradual decline of cognitive and motor functions. Considering an increasing elderly population in the last century, understanding the cellular and molecular mechanisms contributing to brain aging is of vital importance. Recent genetic and transcriptomic findings strongly sug…
  • [Cognitive rehabilitation of patients with neurodegenerative diseases]. [Journal Article]
    Zh Nevrol Psikhiatr Im S S Korsakova. 2020; 120(5):110-115.Levin OS, Bogolepova AN
  • Neurodegenerative diseases are the most common cause of cognitive disorders in the population, but their diagnosis and treatment face a number of difficulties, both purely clinical and organizational. Moreover, neurodegenerative diseases often serve as a background for the development of acute focal brain damage (for example, stroke), limiting the possibility of rehabilitation after them. In addi…
  • Autophagy in motor neuron diseases. [Journal Article]
    Prog Mol Biol Transl Sci. 2020; 172:157-202.Rodríguez-Muela N
  • Motor neuron diseases (MNDs) are a wide group of neurodegenerative disorders characterized by the degeneration of a specific neuronal type located in the central nervous system, the motor neuron (MN). There are two main types of MNs, spinal and cortical MNs and depending on the type of MND, one or both types are affected. Cortical MNs innervate spinal MNs and these control a variety of cellular t…
  • Complete Connectomic Reconstruction of Olfactory Projection Neurons in the Fly Brain. [Journal Article]
    Curr Biol. 2020 Jun 29 [Online ahead of print]Bates AS, Schlegel P, … Jefferis GSXE
  • Nervous systems contain sensory neurons, local neurons, projection neurons, and motor neurons. To understand how these building blocks form whole circuits, we must distil these broad classes into neuronal cell types and describe their network connectivity. Using an electron micrograph dataset for an entire Drosophila melanogaster brain, we reconstruct the first complete inventory of olfactory pro…
  • FABP7 upregulation induces a neurotoxic phenotype in astrocytes. [Journal Article]
    Glia. 2020 Jul 03 [Online ahead of print]Killoy KM, Harlan BA, … Vargas MR
  • Fatty acid binding proteins (FABPs) are key regulators of lipid metabolism, energy homeostasis, and inflammation. They participate in fatty acid metabolism by regulating their uptake, transport, and availability of ligands to nuclear receptors. In the adult brain, FABP7 is especially abundant in astrocytes that are rich in cytoplasmic granules originated from damaged mitochondria. Mitochondrial d…
  • Quantitative patterns of motor cortex proteinopathy across ALS genotypes. [Journal Article]
    Acta Neuropathol Commun. 2020 Jul 02; 8(1):98.Nolan M, Scott C, … Ansorge O
  • Degeneration of the primary motor cortex is a defining feature of amyotrophic lateral sclerosis (ALS), which is associated with the accumulation of microscopic protein aggregates in neurons and glia. However, little is known about the quantitative burden and pattern of motor cortex proteinopathies across ALS genotypes. We combined quantitative digital image analysis with multi-level generalized l…
  • External resistance is imperative for training-induced efferent neural drive enhancement in older adults. [Journal Article]
    J Gerontol A Biol Sci Med Sci. 2020 Jul 02 [Online ahead of print]Unhjem R, Tøien T, … Wang E
  • Strength training performed with heavy loads and maximal intended velocity is documented to enhance efferent neural drive to maximally contracting musculature in older adults. However, it remains unclear whether the neural plasticity following training result from motor skill learning or if external resistance is a prerequisite. To investigate this, we assessed electrically evoked potentials (H-r…
  • Peripheral and Central Nervous System Immune Response Crosstalk in Amyotrophic Lateral Sclerosis. [Review]
    Front Neurosci. 2020; 14:575.Liu Z, Cheng X, … Zhao C
  • Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by muscle weakness due to the degeneration of the upper and lower motor neurons. Neuroinflammation is known as a prominent pathological feature of ALS. Although neuroinflammation cannot trigger ALS, activated central nervous system (CNS) microglia and astrocytes, proinflammatory periphery monocytes/macrophages …
  • The current state of electrocorticography-based brain-computer interfaces. [Journal Article]
    Neurosurg Focus. 2020 Jul; 49(1):E2.Miller KJ, Hermes D, Staff NP
  • Brain-computer interfaces (BCIs) provide a way for the brain to interface directly with a computer. Many different brain signals can be used to control a device, varying in ease of recording, reliability, stability, temporal and spatial resolution, and noise. Electrocorticography (ECoG) electrodes provide a highly reliable signal from the human brain surface, and these signals have been used to d…
  • Conserved metabolite regulation of stress granule assembly via AdoMet. [Journal Article]
    J Cell Biol. 2020 Aug 03; 219(8)Begovich K, Vu AQ, … Wilhelm JE
  • Stress granules (SGs) are evolutionarily conserved condensates of ribonucleoproteins that assemble in response to metabolic stresses. Because aberrant SG formation is associated with amyotrophic lateral sclerosis (ALS), understanding the connection between metabolic activity and SG composition can provide therapeutic insights into neurodegeneration. Here, we identify 17 metabolic enzymes recruite…
  • Functional muscle strength recovery from nail gun injury to the primary motor cortex. [Journal Article]
    Regen Med. 2020 Jul 01 [Online ahead of print]Andereggen L, Widmer HR, … Andres RH
  • Aim: Functional recovery following injury to the primary motor cortex is an uncommon phenomenon, given the limited ability of neurons of the adult central nervous system to regenerate. Case description: We report on a patient with near complete functional muscle strength recovery from a marked monoparesis due to nail gun injury to the medial primary motor cortex. Besides surgical decision-making…
  • Dietary Amino Acids Impact LRRK2-induced Neurodegeneration in Parkinson's Disease Models. [Journal Article]
    J Neurosci. 2020 Jun 30 [Online ahead of print]Chittoor-Vinod VG, Villalobos-Cantor S, … Martin I
  • The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is a common cause of Parkinson's disease (PD) and results in age-related dopamine neuron loss and locomotor dysfunction in Drosophila melanogaster through an aberrant increase in bulk neuronal protein synthesis. Under non-pathologic conditions, protein synthesis is tightly controlled by metabolic regulation. Whether nutritional and metab…
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