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4,751 results
  • Update on invasive fungal infections in the Middle Eastern and North African region. [Review]
    Braz J Microbiol. 2020 Jul 05 [Online ahead of print]Osman M, Al Bikai A, … Hamze M
  • In the recent years, the epidemiology of invasive fungal infections (IFIs) has changed worldwide. This is remarkably noticed with the significant increase in high-risk populations. Although surveillance of such infections is essential, data in the Middle Eastern and North African (MENA) region remain scarce. In this paper, we reviewed the existing data on the epidemiology of different IFIs in the…
  • Tornadic Shear Stress Induces a Transient, Calcineurin-Dependent Hypervirulent Phenotype in Mucorales Molds. [Journal Article]
    mBio. 2020 Jun 30; 11(3)Wurster S, Tatara AM, … Kontoyiannis DP
  • Trauma-related necrotizing myocutaneous mucormycosis (NMM) has a high morbidity and mortality in victims of combat-related injuries, geometeorological disasters, and severe burns. Inspired by the observation that several recent clusters of NMM have been associated with extreme mechanical forces (e.g., during tornados), we studied the impact of mechanical stress on Mucoralean biology and virulence…
  • Mucorales Species and Macrophages. [Review]
    J Fungi (Basel). 2020 Jun 26; 6(2)Nicolás FE, Murcia L, … Garre V
  • Mucormycosis is an emerging fungal infection caused by Mucorales with an unacceptable high mortality rate. Mucorales is a complex fungal group, including eleven different genera that can infect humans. This heterogeneity is associated with species-specific invasion pathways and responses to the host defense mechanisms. The host innate immune system plays a major role in preventing Mucorales growt…
  • Gastric ulcer due to mucormycosis in a critical patient. [Journal Article]
    Rev Esp Enferm Dig. 2020 Jun 24; 112Pérez Fernández A, Rubio Mateos JM, Sánchez Fernández MJ
  • We have read the article published by Sánchez-Velázquez P et al., which described a clinical case of gastrointestinal hemorrhage secondary to gastric ulcer due to Mucor. We present a similar clinical case, as an example of one identified by gastroscopy. The case was a 71-year-old female with multiple organ failure secondary to nosocomial pneumonia who required mechanical ventilation, vasoactive d…
  • Successful treatment of disseminated granulomatous aspergillosis in an apparently immunocompetent host. [Journal Article]
    Trop Doct. 2020 Jun 23 [Online ahead of print]Agrawal U, Savaj P, … Sunavala A
  • A young Indian man presented elsewhere with a short history of haematuria and cough. Investigations revealed renal and pulmonary lesions. Histopathology of these lesions was reported as mucormycosis. He consulted us two months after onset of symptoms, asymptomatic and clinically well, having received no treatment. In view of clinico-histopathological discordance, a review of the biopsy slides was…
  • Rhizoferrin Glycosylation in Rhizopus microsporus. [Journal Article]
    J Fungi (Basel). 2020 Jun 18; 6(2)Škríba A, Patil RH, … Havlíček V
  • Rhizopus spp. are the most common etiological agents of mucormycosis, causing over 90% mortality in disseminated infections. The diagnosis relies on histopathology, culture, and/or polymerase chain reaction. For the first time, the glycosylation of rhizoferrin (RHF) was described in a Rhizopus microsporus clinical isolate by liquid chromatography and accurate tandem mass spectrometry. The ferment…
  • Aspergillus and Rhizopus Fungal Coinfection in a Patient With Multiple Myeloma. [Case Reports]
    Cureus. 2020 May 11; 12(5):e8050.Aqsa A, Droubi S, Glaser A
  • Opportunistic fungal infections are rare but life-threatening in immunocompromised patients. We discuss a case of an immunocompromised patient with multiple myeloma who presented with shortness of breath, fever, ocular palsy, and hemiplegia. She was found to have influenza A respiratory tract infection complicated by invasive aspergillosis and mucormycosis. Investigation revealed invasive fungal …
    AACE Clin Case Rep. 2020 Mar-Apr; 6(2):e62-e64.Araque DP, Zuniga G, Ayala AR
  • CONCLUSIONS: Available data suggest that the adverse effect profile of PSO is more favorable than other triazoles. However, our case is the third report suggesting that PAI may be an underrecognized side effect. Awareness of this complication is particularly important in patients with severe or resistant fungal infections.
  • StatPearls: Rhino-orbital Cerebral Mucormycosis [BOOK]
    . StatPearls Publishing: Treasure Island (FL) AK Ajith Kumar AK Manipal Hospitals Gupta Vikas V South Carolina Department of Mental Health BOOK
  • Taxonomically, the term 'zygomycosis' was used to describe invasive fungal infections caused by Zygomycetes, which are ribbon-shaped (about 5-15 microns in diameter) irregularly branched pauciseptate or aseptate molds which reproduce sexually via formation of zygospores. Subsequently, a reclassification was followed, dividing the above species into two orders, Mucorales and Entomopthorales.[1] Th…
  • GRP78 and Integrins Play Different Roles in Host Cell Invasion during Mucormycosis. [Journal Article]
    mBio. 2020 Jun 02; 11(3)Alqarihi A, Gebremariam T, … Ibrahim AS
  • Mucormycosis, caused by Rhizopus species, is a life-threatening fungal infection that occurs in patients immunocompromised by diabetic ketoacidosis (DKA), cytotoxic chemotherapy, immunosuppressive therapy, hematologic malignancies, or severe trauma. Inhaled Rhizopus spores cause pulmonary infections in patients with hematologic malignancies, while patients with DKA are much more prone to rhinoorb…
  • Mucormycosis in the Middle East and North Africa: Analysis of the FungiScope® registry and cases from the literature. [Journal Article]
    Mycoses. 2020 Jun 02 [Online ahead of print]Stemler J, Hamed K, … Cornely OA
  • CONCLUSIONS: The number of reported cases of mucormycosis in the MENA region has risen over the past few decades, in line with increases in the number of patients with underlying conditions associated with this infection. Although the majority of patients received treatment with antifungal therapies and/or surgery, the associated mortality rate remains high and there is a clear need for more effective prevention and treatment strategies in the MENA region.
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