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11,673 results
  • Dnmt3a is required for the tumor stemness of B16 melanoma cells. [Journal Article]
    Acta Biochim Biophys Sin (Shanghai) 2019Wang H, Kuang Y, … Fei J
  • The relationship of carcinogenesis and DNA methyltransferases has attracted extensive attention in tumor research. We reported previously that inhibition of de novo DNA methyltransferase 3a (Dnmt3a) in murine B16 melanoma cells significantly suppressed tumor growth and metastasis in xenografted mouse model. Here, we further demonstrated that knockdown of Dnmt3a enhanced the proliferation in ancho…
  • NFIC promotes the vitality and osteogenic differentiation of rat dental follicle cells. [Journal Article]
    J Mol Histol 2019Zhang F, Liang M, … Yu S
  • Nuclear factor I-C (NFIC) plays critical roles in the regulation of tooth development by influencing the biological behaviors of stem cells in the dental germ. This study aimed to investigate the effect of NFIC on the vitality and osteogenic/cementogenic differentiation of rat dental follicle cells (DFCs). DFCs were isolated from dental follicles in the first molars of neonatal rats. DFCs express…
  • Mesenchymal Stromal Cell Therapeutic Delivery: Translational Challenges to Clinical Application. [Review]
    Front Immunol 2019; 10:1645Caplan H, Olson SD, … Cox CS
  • For several decades, multipotent mesenchymal stromal cells (MSCs) have been extensively studied for their therapeutic potential across a wide range of diseases. In the preclinical setting, MSCs demonstrate consistent ability to promote tissue healing, down-regulate excessive inflammation and improve outcomes in animal models. Several proposed mechanisms of action have been posited and demonstrate…
  • Niche stiffness underlies the ageing of central nervous system progenitor cells. [Journal Article]
    Nature 2019Segel M, Neumann B, … Chalut KJ
  • Ageing causes a decline in tissue regeneration owing to a loss of function of adult stem cell and progenitor cell populations1. One example is the deterioration of the regenerative capacity of the widespread and abundant population of central nervous system (CNS) multipotent stem cells known as oligodendrocyte progenitor cells (OPCs)2. A relatively overlooked potential source of this loss of func…
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