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12,170 results
  • Bovine peripheral blood MSCs chemotax towards inflammation and embryo implantation stimuli. [Journal Article]
    J Cell Physiol. 2020 Jul 02 [Online ahead of print]Calle A, Gutiérrez-Reinoso MÁ, … Ramírez MÁ
  • Mesenchymal stem cells (MSCs) have a great potential in regenerative medicine because of their multipotential and immunoregulatory capacities, while in early pregnancy they could participate in the immunotolerance of the mother towards the embryo. Peripheral blood constitutes an accessible source of MSCs. We successfully isolated peripheral blood MSC (pbMSCs) lines, with or without previous bone …
  • The impact of stem cells in neuro-oncology: applications, evidence, limitations and challenges. [Journal Article]
    Acta Biomed. 2020 Jun 30; 91(7-S):51-60.Luzzi S, Giotta Lucifero A, … Foiadelli T
  • CONCLUSIONS: Mesenchymal and neuronal SCs are ideal candidates for SCs-based therapy of malignant brain tumors. The spectrum of their possible applications is vast and is mainly based on the homing capacity toward the tumor microenvironment. Availability, delivery route, oncogenicity and ethical issues are the main translational challenges concerning the use of SCs in neuro-oncology.
  • Atelocollagen promotes chondrogenic differentiation of human adipose-derived mesenchymal stem cells. [Journal Article]
    Sci Rep. 2020 Jun 30; 10(1):10678.Kim SA, Sur YJ, … Kim SJ
  • Effective engineering approaches for cartilage regeneration involve a combination of cells and biomaterial scaffolds. Multipotent mesenchymal stem cells (MSCs) are important sources for cartilage regeneration. Atelocollagen provides a suitable substrate for MSC attachment and enhancing chondrogenic differentiation. Here, we assessed the chondrogenic potential of adipose tissue derived human MSCs …
  • Tuning Thermal Dosage to Facilitate Mesenchymal Stem Cell Osteogenesis in Pro-Inflammatory Environment. [Journal Article]
    J Biomech Eng. 2020 Jun 30 [Online ahead of print]Sunderic K, Li C, … Wang S
  • Mesenchymal stem cells (MSCs) are multipotent cells that can replicate and differentiate to different lineages of mesenchymal tissues, potentiating their use in regenerative medicine. Our previous work and other studies have indicated that mild heat shock enhances osteogenesis. However, the influence of pro-inflammatory cytokines on osteogenic differentiation during mildly elevated temperature co…
  • [Problems and prospects of cell therapy for critical ischaemia of lower limbs]. [Journal Article]
    Angiol Sosud Khir. 2020; 26(2):23-33.Osipova OS, Saaia SB, … Zakiian SM
  • CONCLUSIONS: It is supposed that treatment with stem cells or precursor cells is more efficient as compared to protein or gene therapy not only owing to direct vasculogenic properties but a paracrine action through excretion of proangiogenic biologically active substances. More studies with larger cohorts are necessary to provide stronger safety and efficacy data on cell therapy. Besides, a promising trend in the field of cellular approaches is modulation of regenerative capability of stem cells, which may help overcome difficulties in understanding the place of cell therapy in therapeutic angiogenesis.
  • Lineage-restricted sympathoadrenal progenitors confer neuroblastoma origin and its tumorigenicity. [Journal Article]
    Oncotarget. 2020 Jun 16; 11(24):2357-2371.Yang CL, Serra-Roma A, … Shakhova O
  • Neuroblastoma (NB) is the most common cancer in infants and it accounts for six percent of all pediatric malignancies. There are several hypotheses proposed on the origins of NB. While there is little genetic evidence to support this, the prevailing model is that NB originates from neural crest stem cells (NCSCs). Utilizing in vivo mouse models, we demonstrate that targeting MYCN oncogene to NCSC…
  • Microvascular Fragments: More Than Just Natural Vascularization Units. [Review]
    Trends Biotechnol. 2020 Jun 24 [Online ahead of print]Laschke MW, Später T, Menger MD
  • Adipose tissue-derived microvascular fragments serve as natural vascularization units in angiogenesis research and tissue engineering due to their ability to rapidly reassemble into microvascular networks. Recent studies indicate that they exhibit additional unique properties that may be beneficial for a wide range of future biomedical applications. Their angiogenic activity can be increased duri…
  • Roles for receptor tyrosine kinases in tumor progression and implications for cancer treatment. [Journal Article]
    Adv Cancer Res. 2020; 147:1-57.Ghosh S, Marrocco I, Yarden Y
  • Growth factors and their receptor tyrosine kinases (RTKs), a group of transmembrane molecules harboring cytoplasm-facing tyrosine-specific kinase functions, play essential roles in migration of multipotent cell populations and rapid proliferation of stem cells' descendants, transit amplifying cells, during embryogenesis and tissue repair. These intrinsic functions are aberrantly harnessed when ca…
  • Adipose tissue in health and disease through the lens of its building blocks. [Journal Article]
    Sci Rep. 2020 Jun 26; 10(1):10433.Lenz M, Arts ICW, … Ertaylan G
  • Understanding adipose tissue cellular heterogeneity and homeostasis is essential to comprehend the cell type dynamics in metabolic diseases. Cellular subpopulations in the adipose tissue have been related to disease development, but efforts towards characterizing the adipose tissue cell type composition are limited. Here, we identify the cell type composition of the adipose tissue by using gene e…
  • The platelet-rich plasma and mesenchymal stem cell milieu: A review of therapeutic effects on bone healing. [Review]
    J Orthop Res. 2020 Jun 26 [Online ahead of print]Liebig BE, Kisiday JD, … Goodrich LR
  • Platelet-rich plasma is autologous plasma that contains concentrated platelets compared to whole blood. It is relatively inexpensive to produce, can be easily isolated from whole blood, and can be administered while the patient is in the operating room. Further, because platelet-rich plasma is an autologous therapy, there is minimal risk for adverse reactions to the patient. Platelet-rich plasma …
  • Regenerative medicine of pancreatic islets. [Review]
    World J Gastroenterol. 2020 Jun 14; 26(22):2948-2966.Arutyunyan IV, Fatkhudinov TK, … Sukhikh GT
  • The pancreas became one of the first objects of regenerative medicine, since other possibilities of dealing with the pancreatic endocrine insufficiency were clearly exhausted. The number of people living with diabetes mellitus is currently approaching half a billion, hence the crucial relevance of new methods to stimulate regeneration of the insulin-secreting β-cells of the islets of Langerhans. …
  • The Role of Lysophosphatidic Acid in Adult Stem Cells. [Review]
    Int J Stem Cells. 2020 Jun 30 [Online ahead of print]Lee D, Kim YH, Kim JH
  • Stem cells are undifferentiated multipotent precursor cells that are capable both of perpetuating themselves as stem cells (self-renewal) and of undergoing differentiation into one or more specialized types of cells. And these stem cells have been reported to reside within distinct anatomic locations termed "niches". The long-term goals of stem cell biology range from an understanding of cell-lin…
  • The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing. [Journal Article]
    Annu Rev Cell Dev Biol. 2020 Jun 24 [Online ahead of print]Pucella JN, Upadhaya S, Reizis B
  • The generation of all blood cell lineages (hematopoiesis) is sustained throughout the entire life span of adult mammals. Studies using cell transplantation identified the self-renewing, multipotent hematopoietic stem cells (HSCs) as the source of hematopoiesis in adoptive hosts and delineated a hierarchy of HSC-derived progenitors that ultimately yield mature blood cells. However, much less is kn…
  • Functional Heterogeneity of Protein Kinase A Activation in Multipotent Stromal Cells. [Journal Article]
    Int J Mol Sci. 2020 Jun 22; 21(12)Tyurin-Kuzmin PA, Karagyaur MN, … Tkachuk VA
  • Multipotent stromal cells (MSC) demonstrate remarkable functional heterogeneity; however, its molecular mechanisms remain largely obscure. In this study, we explored MSC response to hormones, which activate Gs-protein / cyclic AMP (cAMP) / protein kinase A (PKA) dependent signaling, at the single cell level using genetically encoded biosensor PKA-Spark. For the first time, we demonstrated that ab…
  • A circular RNA map for human induced pluripotent stem cells of foetal origin. [Journal Article]
    EBioMedicine. 2020 Jun 20; 57:102848.Barilani M, Cherubini A, … Lazzari L
  • CONCLUSIONS: A circRNA map of transcripts associated to naïve and primed pluripotency is provided for hiPSC of clinical-grade foetal origin, offering insights on still unreported regulatory circuits of the PGRN to consider for the optimization and development of efficient differentiation protocols for clinical translation.
  • RNA-sequencing reveals positional memory of multipotent mesenchymal stromal cells from oral and maxillofacial tissue transcriptomes. [Journal Article]
    BMC Genomics. 2020 Jun 22; 21(1):417.Onizuka S, Yamazaki Y, … Iwata T
  • CONCLUSIONS: Our findings suggest that MSCs from different anatomical locations, despite meeting general characterization criteria, have remarkable differences in gene expression and positional memory. Although stromal cells from different anatomical sources are generally categorized as MSCs, their differentiation potential and biological functions vary. We suggested that MSCs may retain an original tissue memory about the developmental process, including gene expression profiles. This could have an important impact when choosing an appropriate cell source for regenerative therapy using MSCs.
  • Stabilizing hematopoietic stem cells in vitro. [Review]
    Curr Opin Genet Dev. 2020 Jun 19; 64:1-5.Wilkinson AC, Nakauchi H
  • Hematopoietic stem cells (HSCs) can regenerate all lineages of the adult blood and immune systems long-term following transplantation via a combination of self-renewal and multipotent differentiation. HSCs are therefore an important cell type in both basic research and in the clinic, where HSC transplantation is a curative therapy for a range of diseases. However, as a rare bone marrow cell popul…
  • Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. [Review]
    Int J Mol Sci. 2020 Jun 16; 21(12)Ambele MA, Dhanraj P, … Pepper MS
  • The formation of adipocytes during embryogenesis has been largely understudied. However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem cells which migrate from the mesoderm to their anatomical localization. Most studies on adipocyte formation (adipogenesis) have used preadipocytes derived from adult stem/stromal cells. Adipogenesis consists of two phases, namely comm…
  • Origin and Lineage Plasticity of Endogenous Lacrimal Gland Epithelial Stem/Progenitor Cells. [Journal Article]
    iScience. 2020 Jun 26; 23(6):101230.Basova L, Parfitt GJ, … Makarenkova HP
  • The lacrimal gland (LG) is an exocrine organ responsible for the secretion of aqueous tear film. Regenerative and stem cell therapies that target LG repair are coming to the fore, although our understanding of LG cell lineage hierarchy is still incomplete. We utilize the analysis of label-retaining cells (LRCs) and genetic lineage tracing to define LG cell lineage hierarchy. Our study suggests th…
  • [Hematopoietic Stem Cells Differentiate into the Megakaryocyte Lineage--Review]. [Journal Article]
    Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Jun; 28(3):1044-1048.Zhang S, Dong F, … Ema H
  • Abstract  Hematopoietic stem cells are able to self-renewal and differentiate to all blood lineages. With the development of new technologies, recent studies have proposed the revised versions of hematopoiesis. In the classical model of hematopoietic differentiation, HSCs were located at the apex of hematopoietic hierarchy. During differentiation process, HSCs progressively lose self-renewal pote…
  • A Giant Ganglion Cyst Arising from Lateral Hoffa's Fat Pad of the Knee. [Case Reports]
    J Orthop Case Rep. 2020; 9(6):36-39.Vaishya R, Kansagra A, … Vijay V
  • CONCLUSIONS: Cysts and cystic-appearing lesions around the knee are not uncommon, but a ganglion cyst arising from HFP is rare. The presence of multipotent cells in the HFP may be responsible for producing a variety of cyst and cyst-like tumors around the anterior aspect of the knee joint. An MRI is the best imaging modality for the diagnosis of these cysts and cysts-like lesions around the knee. We recommend that the smaller intra-articular lesions can be resected arthroscopically, but larger lesions, with extraarticular extension, are best treated by open resection to avoid incomplete excision and recurrence.
  • Current and future uses of skeletal stem cells for bone regeneration. [Review]
    World J Stem Cells. 2020 May 26; 12(5):339-350.Xu GP, Zhang XF, … Chen EM
  • The postnatal skeleton undergoes growth, modeling, and remodeling. The human skeleton is a composite of diverse tissue types, including bone, cartilage, fat, fibroblasts, nerves, blood vessels, and hematopoietic cells. Fracture nonunion and bone defects are among the most challenging clinical problems in orthopedic trauma. The incidence of nonunion or bone defects following fractures is increasin…
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