- Low-grade appendiceal mucinous neoplasms confined to the appendix: clinical manifestations and CT findings. [Journal Article]
- JIJ Investig Med 2019 Jul 11
- The clinical findings and CT images are investigated in order to fulfill an early preoperative diagnosis and increase awareness of low-grade appendiceal mucinous neoplasm (LAMN) confined to the appen…
The clinical findings and CT images are investigated in order to fulfill an early preoperative diagnosis and increase awareness of low-grade appendiceal mucinous neoplasm (LAMN) confined to the appendix. 17 cases with histologically proven LAMNs confined to the appendix were included in this study. All patients had received multiphase CT examinations before the surgery. The imaging criteria included shape, size, margin, attenuation, secondary degeneration and internal mass enhancement pattern. In CT images, all cases appeared as oval or tubular cystic masses (average attenuation 20.4±3.6 Hounsfield units), with the longest dimensions ranging from approximately 38 to 106 mm (mean 66.3 mm), and the ratio of length against width was 1.83 in average. The cystic wall was unevenly thickened, with a mean maximal wall thickness of 5.7 mm (>10 mm in 3 cases). The inner capsule wall was rough, and calcification was observed in 3 cases. A few amounts of periappendiceal fat stranding were noted in 2 cases. Mild ring mural enhancement of the cystic wall was seen during the arterial phase, with progressive enhancement during the portal venous phase. In addition, mini enhancing mural nodules was observed in 5 cases. Although preoperative diagnosis of LAMNs confined to the appendix remains challenging, it should be considered when a focal well-defined cystic mass with slightly higher than water attenuation, thickened cystic wall with ring mural enhancement and a characteristic progressive contrast enhancement in CT imaging, especially in older females with non-specific symptoms similar to appendicitis.
- Inhibition of VEGF (Vascular Endothelial Growth Factor)-A or its Receptor Activity Suppresses Experimental Aneurysm Progression in the Aortic Elastase Infusion Model. [Journal Article]
- ATArterioscler Thromb Vasc Biol 2019 Jul 11; :ATVBAHA119312497
- CONCLUSIONS: VEGF-A and its receptors contribute to experimental AAA formation by suppressing mural angiogenesis, MMP and VEGF-A production, myeloid cell chemotaxis, and circulating monocytes. Pharmacological inhibition of receptor tyrosine kinases by sunitinib or related compounds may provide novel opportunities for clinical aneurysm suppression.
- Fatal Rameshwarotrema uterocrescens infection with ulcerative esophagitis and intravascular dissemination in green turtles. [Journal Article]
- IJInt J Parasitol Parasites Wildl 2019; 9:281-284
- The trematode Rameshwarotrema uterocrescens (Digenea: Pronocephalidae) parasitizes the glands of the caudal esophagus of Chelonia mydas. In the present study, 741 C. mydas were examined, 85 animals h…
The trematode Rameshwarotrema uterocrescens (Digenea: Pronocephalidae) parasitizes the glands of the caudal esophagus of Chelonia mydas. In the present study, 741 C. mydas were examined, 85 animals had adult specimens of R. uterocrescens associated with necrotizing ulcerous esophagitis, of these 85, 21 presented invasion of the esophageal mural vessels in the caudal esophagus of juvenile green turtles (Chelonia mydas). Necrotizing granulomatous splenitis, hepatitis, and nephritis were associated with the presence of parasites. The eggs from R. uterocrescens are birefringent under plane-polarized light, which distinguishes them from those of spirorchiid trematodes. This study contributes novel data on R. uterocrescens, methods for detecting this parasite, and demonstrates the fatal potential of parasitism in C. mydas.
- Contrast-enhanced endoscopic ultrasound diagnosis of the intraductal papillary mucinous neoplasm. [Journal Article]
- CJClin J Gastroenterol 2019 Jul 06
- Pancreatic cystic neoplasms (PCNs) are a frequent incidental finding during an ultrasound or other radiological investigations. As PCNs may have a potential of malignancy, a precise differential diag…
Pancreatic cystic neoplasms (PCNs) are a frequent incidental finding during an ultrasound or other radiological investigations. As PCNs may have a potential of malignancy, a precise differential diagnosis between a malignant and benign lesion is crucial to define appropriate management of patients with this kind of lesions. Radiology, with computed tomography (CT) and magnetic resonance imaging, may not be conclusive in the diagnostic assessment of PCNs. Endoscopic ultrasound (EUS), a simple and relatively low invasive technique, is able to identify intra-cystic worrisome features suggesting malignancy. Fine-needle aspiration (FNA) of the cystic fluid or of intra-cystic tissue nodule during EUS is an adjunctive procedure for reaching a conclusive diagnosis. As EUS-FNA is burdened by complications, the use of intravenous contrast may increase the diagnostic accuracy of EUS allowing in many cases a correct diagnosis of PCN at high risk of malignancy, without additional risk of complication during the procedure. The present report deals with the case of a cystic lesion found by CT scan in the pancreatic head of a 59-year-old woman suffering from mild epigastric pain. Once submitted to EUS, malignant nature of PCN was suspected due to the finding of a typical worrisome feature, the presence of a mural nodule. The intravenous administration of contrast medium during the EUS confirmed malignancy and the patient was immediately sent to the surgeon for pancreatic resection. Histology revealed an intraductal papillary mucinous neoplasm, with areas of high-grade dysplasia in the main and secondary ducts, progressed toward an invasive carcinoma.
- Clivus Hemangioma in a pediatric patient: Case report. [Journal Article]
- WNWorld Neurosurg 2019 Jul 04
- CONCLUSIONS: Surgical safety margins are highly important to prevent recurrence in this type of bone tumors. Skull base hemangiomas are a big challenge when you want to achieve these safety margins. We believe that a combined treatment of surgery and radiotherapy should be considered as the main treatment.
- Poorly differentiated mucinous carcinoma with signet ring cells in an ovarian endometriotic cyst: a case report. [Journal Article]
- DPDiagn Pathol 2019 Jul 06; 14(1):73
- CONCLUSIONS: Primary ovarian poorly differentiated mucinous carcinoma with signet ring cells can occur in an atypical endometriotic cyst. This rare case addresses the necessity of careful and extensive pathological examination on large ovarian endometriotic cysts.
- Surgical Therapy for Angiosarcoma of the Aorta: A Case Report. [Journal Article]
- AVAnn Vasc Dis 2019 Jun 25; 12(2):225-227
- We describe the case of a 71-year-old woman presenting with abdominal angina with an intra-aortic mass at the thoracoabdominal aorta that restricted blood supply to the organs. Initially, the intra-a…
We describe the case of a 71-year-old woman presenting with abdominal angina with an intra-aortic mass at the thoracoabdominal aorta that restricted blood supply to the organs. Initially, the intra-aortic mass was suspected to be a mural thrombus; thus, endarterectomy was performed. However, postoperative histopathological examination revealed an intimal sarcoma, which relapsed locally within a few months. Additional en bloc resection of the aorta with graft interposition was performed. Despite surgical therapy, splenic metastasis was detected a few months after the second surgery; therefore, palliative care was selected for the patient.
- Type 1 Autoimmune Pancreatitis with Imaging Appearance Similar to That of Malignant Cystic Tumor. [Case Reports]
- CRCase Rep Gastroenterol 2019 May-Aug; 13(2):265-270
- A 79-year-old man was admitted with asymptomatic elevation of liver enzymes and tumor markers. Abdominal contrast-enhanced computed tomography demonstrated swelling of the pancreatic head, and additi…
A 79-year-old man was admitted with asymptomatic elevation of liver enzymes and tumor markers. Abdominal contrast-enhanced computed tomography demonstrated swelling of the pancreatic head, and additional blood test showed raised IgG4 levels. Histological examination by endoscopic ultrasonography (EUS)-guided fine needle aspiration for pancreatic head mass revealed storiform fibrosis and IgG4-positive plasma cell infiltration. We diagnosed this case as type 1 autoimmune pancreatitis (AIP). In addition, there was a cystic lesion in the pancreatic body apart from the pancreatic head mass. A mural nodule in the multilocular cyst was detected by EUS, and there was positive uptake of fluorodeoxyglucose in positron emission tomography/magnetic resonance imaging. The preoperative diagnosis of this cystic lesion was intraductal papillary mucinous carcinoma, and distal pancreatomy was performed. Histopathological findings showed various sizes of retention cysts caused by IgG4-positive plasma cell infiltration around the pancreatic branch ducts. The mural nodule was a fibrotic mass with diffuse infiltration of IgG4-positive cells. This cystic lesion mimicking malignant cystic neoplasm occurred in relation to AIP. This case provided important information helping to understand the mechanism of formation of mural nodules in multilocular cysts in patients with type 1 AIP.
- Novel TEM Microscopy and Electron Diffraction Techniques to Characterize Cultural Heritage Materials: From Ancient Greek Artefacts to Maya Mural Paintings. [Journal Article]
- SScanning 2019; 2019:4870695
- To understand in-depth material properties, manufacturing, and conservation in cultural heritage artefacts, there is a strong need for advanced characterization tools that enable analysis down to the…
To understand in-depth material properties, manufacturing, and conservation in cultural heritage artefacts, there is a strong need for advanced characterization tools that enable analysis down to the nanometric scale. Transmission electron microscopy (TEM) and electron diffraction (ED) techniques, like 3D precession electron diffraction tomography and ASTAR phase/orientation mapping, are proposed to study cultural heritage materials at nanoscale. In this work, we show how electron crystallography in TEM helps to determine precise structural information and phase/orientation distribution of various pigments in cultural heritage materials from various historical periods like Greek amphorisks, Roman glass tesserae, and pre-Hispanic Maya mural paintings. Such TEM-based methods can be an alternative to synchrotron techniques and can allow distinguishing accurately different crystalline phases even in cases of identical or very close chemical compositions at the nanometric scale.
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- Cellular Control of Brain Capillary Blood Flow: In Vivo Imaging Veritas. [Review]
- TNTrends Neurosci 2019 Jun 26
- The precise modulation of regional cerebral blood flow during neural activation is important for matching local energetic demand and supply and clearing brain metabolites. Here we discuss advances fa…
The precise modulation of regional cerebral blood flow during neural activation is important for matching local energetic demand and supply and clearing brain metabolites. Here we discuss advances facilitated by high-resolution optical in vivo imaging techniques that for the first time have provided direct visualization of capillary blood flow and its modulation by neural activity. We focus primarily on studies of microvascular flow, mural cell control of vessel diameter, and oxygen level-dependent changes in red blood cell deformability. We also suggest methodological standards for best practices when studying microvascular perfusion, partly motivated by recent controversies about the precise location within the microvascular tree where neurovascular coupling is initiated, and the role of mural cells in the control of vasomotility.