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(muscle fiber)
23,711 results
  • Life-threatening muscle complications of COL4A1-related disorder. [Journal Article]
    Brain Dev 2019Okano S, Shimada S, … Azuma H
  • COL4A1-related disorder is recognized as a systemic disease because the alpha 1 chain of type IV collagen, encoded by COL4A1, is essential for basement membrane stability. However, muscular manifestations related to this disorder are rarely reported. We report the case of a 2-year-old boy with porencephaly, who harbored a de novo COL4A1 mutation of c.1853G > A, p. (Gly618Glu) and exhibited recurr…
  • Skeletal muscle-derived cells repair peripheral nerve defects in mice. [Journal Article]
    Neural Regen Res 2020; 15(1):152-161Chen ZX, Lu HB, … Qi ZL
  • Skeletal muscle-derived cells have strong secretory function, while skeletal muscle-derived stem cells, which are included in muscle-derived cells, can differentiate into Schwann cell-like cells and other cell types. However, the effect of muscle-derived cells on peripheral nerve defects has not been reported. In this study, 5-mm-long nerve defects were created in the right sciatic nerves of mice…
  • Nerve Excitability Differences in Slow and Fast Motor Axons of the Rat: more than just Ih. [Journal Article]
    J Neurophysiol 2019Bell JM, Lorenz C, Jones KE
  • CONCLUSIONS: Nerve excitability indices measured with SP show definitive differences between TA and SOL motor axons that extend beyond previous reports. Nerve excitability indices sensitive to changes in Ih indicated an increase in SOL axons compared to TA axons (e.g. S3 t=7.949 (df=10), p<0.001; TEh (90-100 ms), t=2.659 (df=20), p=0.01; hyperpolarizing I/V slope, t=4.308 (df=19), p<0.001). SOL axons also had a longer strength-duration time constant (t=3.35 (df=20), p=0.003) and a longer and larger magnitude relative refractory period (t=3.53 (df=12), p=0.004; Refractoriness t=0.0055 (df=9), p=0.006).Anaesthetic choice affected many measures of peripheral nerve excitability with differences most apparent in threshold electrotonus and recovery cycle. For example, recovery cycle with KX lacked a clear superexcitable and late subexcitable period. We conclude that KX had a confounding effect on nerve excitability results consistent with ischaemic depolarization. Results using SP revealed the full extent of differences in nerve excitability measures between putative slow and fast motor axons of the rat. These results provide empirical evidence that the biophysical properties of motor axons vary with the type of muscle fiber innervated. These differences suggest that fast axons may be predisposed to dysfunction during hyperpolarizing stresses.
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