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113,679 results
  • Application of the Adverse Outcome Pathway (AOP) Framework to Genotoxic Modes of Action (MOA). [Journal Article]
    Environ Mol Mutagen 2019Sasaki JC, Allemang A, … Schuler M
  • In May 2017, the Health and Environmental Sciences Institute's Genetic Toxicology Technical Committee hosted a workshop to discuss whether mode of action (MOA) investigation is enhanced through the application of the adverse outcome pathway (AOP) framework. As AOPs are a relatively new approach in genetic toxicology, this report describes how AOPs could be harnessed to advance MOA analysis of gen…
  • Commentary: Mutation as a toxicological endpoint for regulatory decision-making. [Journal Article]
    Environ Mol Mutagen 2019Heflich RH, Johnson GE, … White PA
  • Mutations induced in somatic cells and germ cells are responsible for a variety of human diseases, and mutation per se has been considered an adverse health concern since the early part of the 20th Century. Although in vitro and in vivo somatic cell mutation data are most commonly used by regulatory agencies for hazard identification, that is, determining whether or not a substance is a potential…
  • Adventures with Bruce Ames and the Ames test. [Journal Article]
    Mutat Res 2019; 846:403070Marnett LJ
  • Bruce Ames has had an enormous impact on human health by developing facile methods for the identification of mutagens. This research also provided important insights into the relationship between mutagenesis and carcinogenesis. Bruce is a highly innovative and creative individual who has followed his interests across disciplines into diverse fields of inquiry. The present author had the pleasure …
  • In Vivo Localization and Postmortem Stability of Benzo[a]pyrene-DNA Adducts. [Journal Article]
    Environ Mol Mutagen 2019Poirier MC, Beland FA, … Martineau D
  • DNA adducts of carcinogenic polycyclic aromatic hydrocarbons (PAHs) play a critical role in the etiology of gastrointestinal tract cancers in humans and other species orally exposed to PAHs. Yet, the precise localization of PAH-DNA adducts in the gastrointestinal tract, and the long-term postmortem PAH-DNA adduct stability are unknown. To address these issues, the following experiment was perform…
  • Evidence for an Aneugenic Mechanism of Action for Micronucleus Induction by Black Cohosh Extract. [Journal Article]
    Environ Mol Mutagen 2019Bernacki DT, Bryce SM, … Smith-Roe SL
  • Black cohosh extract (BCE) is a popular botanical dietary supplement marketed to relieve symptoms of various gynecological ailments. Studies conducted by the National Toxicology Program (NTP) showed that BCE induces micronucleated erythrocytes in female rats and mice. Subsequently, the NTP showed that a variety of BCEs, including the sample that induced micronuclei (MN) in vivo ("NTP BCE") had a …
  • Contribution of GO System Glycosylases to Mutation Prevention in Caulobacter crescentus. [Journal Article]
    Environ Mol Mutagen 2019Fernández-Silva FS, Schulz ML, … Galhardo RS
  • 8-oxo-7,8-dihydroguanine, commonly referred to as 8-oxoG, is considered one of the most predominant oxidative lesions formed in DNA. Due to its ability to pair with adenines in its syn configuration, this lesion has a strong mutagenic potential in both eukaryotes and prokaryotes. Escherichia coli cells are endowed with the GO system, which protects them from the mutagenic properties of this lesio…
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