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112,957 results
  • The phage T4 DNA ligase in vivo improves the survival-coupled bacterial mutagenesis. [Journal Article]
  • MCMicrob Cell Fact 2019 Jun 13; 18(1):107
  • Wang J, Liu F, … Qi Q
  • CONCLUSIONS: Expression of T4 DNA ligase in vivo could notably enhance microbial survival to excess chromosomal damages caused by various mutagens. Potential application of T4 DNA ligase in microbial mutagenesis was explored by mutating and screening PHB producing E. coli XLPHB strain. When applied to atmospheric and room temperature plasma (ARTP) microbial mutagenesis, large survival pool was obtained. Mutants available for subsequent screening for desirable features. The use of T4 DNA ligase we were able to quickly improve the PHB production by generating a larger viable mutants pool. This method is a universal strategy can be employed in wide range of bacteria. It indicated that traditional random mutagenesis became more powerful in combine with modern genetic molecular biology and has exciting prospect.
  • [Cancer Surveillance in Inflammatory Bowel Diseases]. [Journal Article]
  • DMDtsch Med Wochenschr 2019; 144(11):753-756
  • Lissner D, Siegmund B
  • Patients with ulcerative colitis and Crohn's colitis, especially in the presence of primary sclerosing cholangitis, have an increased risk of developing colorectal cancer due to the longstanding colo…
  • Effects of light on aging and longevity. [Journal Article]
  • ARAgeing Res Rev 2019 May 30; 53:100913
  • Shen J, Tower J
  • Increasing evidence suggests an important role for light in regulation of aging and longevity. UV radiation is a mutagen that can promote aging and decrease longevity. In contrast, NIR light has show…
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