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99,749 results
  • Cortical quantitative MRI parameters are related to the cognitive status in patients with relapsing-remitting multiple sclerosis. [Journal Article]
    Eur Radiol 2019van Wijnen A, Petrov F, … Gracien RM
  • CONCLUSIONS: Microstructural changes are distributed heterogeneously across the cortex in RRMS/CIS. QMRI has the potential to provide surrogate parameters for the assessment of cognitive impairment in these patients for clinical studies. The characteristics of cognitive impairment in RRMS might depend on the distribution of cortical changes.• The goal of the presented study was to investigate cortical changes in RRMS/CIS and their relation to the cognitive status, using multiparametric quantitative MRI. • Cortical T2, T2*, and PD increases observed in patients appeared heterogeneous across the cortex and their distribution differed between the parameters. • Vertex-wise correlation of T2 with neuropsychological scores revealed specific patterns of cortical changes being related to distinct cognitive deficits.
  • Repeat Expansions in Leukoencephalopathy. [Journal Article]
    Ann Neurol 2019Paulson H
  • Adult onset leukoencephalopathy is a heterogeneous condition that often poses a diagnostic challenge. After infectious, inflammatory, neoplastic, drug-induced and acquired demyelinating disorders have been excluded, the range of potential genetic causes is daunting. Even in this era of next-generation sequencing and targeted disease gene panels, the precise genetic diagnosis often remains elusive…
  • Inhibition of Piezo1 attenuates demyelination in the central nervous system. [Journal Article]
    Glia 2019Velasco-Estevez M, Gadalla KKE, … Sheridan GK
  • Piezo1 is a mechanosensitive ion channel that facilitates the translation of extracellular mechanical cues to intracellular molecular signaling cascades through a process termed, mechanotransduction. In the central nervous system (CNS), mechanically gated ion channels are important regulators of neurodevelopmental processes such as axon guidance, neural stem cell differentiation, and myelination …
  • Towards a Comprehensive Etiopathogenetic and Pathophysiological Theory of Multiple Sclerosis. [Journal Article]
    Int J Neurosci 2019; :1-41Tobore TO
  • Multiple sclerosis (MS) is a neurodegenerative disease caused by dysfunction of the immune system that affects the central nervous system (CNS). It is characterized by demyelination, chronic inflammation, neuronal and oligodendrocyte loss and reactive astrogliosis. It is a can result in physical disability and acute neurological and cognitive problems. Despite the gains in knowledge of immunology…
  • Central Pontine Myelinosis and Osmotic Demyelination Syndrome. [Journal Article]
    Dtsch Arztebl Int 2019; 116(35-36):600-606Lambeck J, Hieber M, … Niesen WD
  • CONCLUSIONS: ODS is a secondary neurological illness resulting from a foregoing primary disease. Though rare overall, it occurs with greater frequency in certain groups of patients. Clinicians of all specialties should therefore be familiar with the risk constellations, clinical presentation, and prevention of ODS. The treatment of ODS is still experimental at present, as no evidence-based treatment is yet available.
  • Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells. [Journal Article]
    Cell Stem Cell 2019; 25(4):473-485.e8Neumann B, Baror R, … Franklin RJM
  • The age-related failure to produce oligodendrocytes from oligodendrocyte progenitor cells (OPCs) is associated with irreversible neurodegeneration in multiple sclerosis (MS). Consequently, regenerative approaches have significant potential for treating chronic demyelinating diseases. Here, we show that the differentiation potential of adult rodent OPCs decreases with age. Aged OPCs become unrespo…
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