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28,054 results
  • StatPearls: Transverse Myelitis [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Simone Christopher G. CG Mercy Catholic Medical Center Emmady Prabhu D. PD UNC school of Medicine, Atrium Health BOOK
  • Transverse myelitis (TM) is a rare, acquired focal inflammatory disorder often presenting with rapid onset weakness, sensory deficits, and bowel/bladder dysfunction. Generally occurring independently; often as a complication of infection; however, it may also exist as part of a continuum of other neuro-inflammatory disorders.[1] Some of the included continua are acute disseminated encephalomyelit…
  • The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings. [Journal Article]
    Brain. 2020 Jul 08 [Online ahead of print]Paterson RW, Brown RL, … UCL Queen Square National Hospital for Neurology and Neurosurgery COVID-19 Study Group
  • Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological and neuropsychiatric illness. Responding to this, a weekly virtual coronavirus disease 19 (COVID-19) neurology multi-disciplinary meeting was established at the National Hospital, Queen Square, in early March 2020 in order to discuss and begin to understan…
  • Cell-based assays for the detection of MOG antibodies: a comparative study. [Journal Article]
    J Neurol. 2020 Jul 04 [Online ahead of print]Gastaldi M, Scaranzin S, … Franciotta D
  • CONCLUSIONS: LCBA-IgG1 showed the highest specificity but can miss MOG-IgG2 reactivities, whose meaning warrants further investigations. Titration of samples tested with LCBA-IgGH+L/ IgGFcγ is important for meaningful interpretation of the results. In the subgroup analysis, LCBA-IgGFcγ yielded the highest accuracy, and FCBA-IgGFcγ good specificity, but it was at risk of false-negative results.
  • Autoimmune and demyelinating optic neuritis. [Review]
    Arch Soc Esp Oftalmol. 2020 Jul 01 [Online ahead of print]García Ortega A, Montañez Campos FJ, … Sanchez-Dalmau B
  • The knowledge on demyelinating and autoimmune optic neuropathies has experienced a revolution the last decade since the discovery of anti-aquaporin 4 antibody. Improvements in diagnostic techniques, and the finding of new targets, along with advances in neuro-immunology have led to the detection of antibodies related to demyelinating diseases. A review is presented on the classical and new concep…
  • Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease. [Journal Article]
    Sci Immunol. 2020 Jul 03; 5(49)Vogt MR, Fu J, … Crowe JE
  • Enterovirus D68 (EV-D68) causes outbreaks of respiratory illness, and there is increasing evidence that it causes outbreaks of acute flaccid myelitis (AFM). There are no licensed therapies to prevent or treat EV-D68 infection or AFM disease. We isolated a panel of EV-D68-reactive human monoclonal antibodies that recognize diverse antigenic variants from participants with prior infection. One pote…
  • Atypical MOG antibody disease presenting with typical multiple sclerosis lesions. [Journal Article]
    Mult Scler Relat Disord. 2020 Jun 26; 44:102342.Dolbec K, Chalkley J, Sudhakar P
  • Myelin oligodendrocyte glycoprotein (MOG) antibody disease is an autoimmune disease of the central nervous system associated with a serological antibody against MOG, a glycoprotein expressed on the outer membrane of myelin. It is solely found within the central nervous system in the brain, optic nerves and spinal cord. MOG antibody disease falls within the neuromyelitis optica spectrum disorders …
  • Impact of multiple sclerosis risk loci in postinfectious neurological syndromes. [Journal Article]
    Mult Scler Relat Disord. 2020 Jun 24; 44:102326.Martinelli-Boneschi F, Currò R, … Marchioni E
  • CONCLUSIONS: The distinction between MS and PINS is not easy to make in clinical practice. However, our study shows that the new set of MS risk alleles does not confer increased susceptibility to PINS. These data support the importance to discriminate these cases from MS with pathophysiological and therapeutic implications.
  • A case of possible atypical demyelinating event of the central nervous system following COVID-19. [Case Reports]
    Mult Scler Relat Disord. 2020 Jun 24; 44:102324.Zoghi A, Ramezani M, … Sahraian MA
  • After the novel coronavirus disease outbreak first began in Wuhan, China, in December 2019, the viral epidemic has quickly spread across the world, and it is now a major public health concern. Here we present a 21-year-old male with encephalomyelitis following intermittent vomiting and malaise for 4 days. He reported upper respiratory signs and symptoms 2 weeks before this presentation. Two cereb…
  • Relapse Patterns in NMOSD: Evidence for Earlier Occurrence of Optic Neuritis and Possible Seasonal Variation. [Journal Article]
    Front Neurol. 2020; 11:537.Khalilidehkordi E, Clarke L, … Broadley SA
  • Neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) show overlap in their clinical features. We performed an analysis of relapses with the aim of determining differences between the two conditions. Cases of NMOSD and age- and sex-matched MS controls were collected from across Australia and New Zealand. Demographic and clinical information, including relapse histories, were…
  • Pneumococcal Meningitis Complicated by Spinal Cord Dysfunction and Acute Polyradiculopathy. [Case Reports]
    Ochsner J. 2020 Summer; 20(2):219-221.Abdallah MA, Ahmed KM, … Khalid M
  • Background: Meningitis caused by Streptococcus pneumoniae is associated with devastating clinical outcomes. A considerable number of patients will develop long-term neurologic complications. Hearing loss, diffuse brain edema, and hydrocephalus are frequently encountered. Acute spinal cord dysfunction and polyradiculopathy can develop in some patients. Case Report: A 63-year-old female was admitt…
  • Radiological characteristics of neuromyelitis optica spectrum disorder in Kuwait. [Journal Article]
    Clin Neurol Neurosurg. 2020 Jun 24; 196:106047.Ismail II, Ahmed SF, … Alroughani R
  • CONCLUSIONS: This is the first study describing the radiological characteristics of NMOSD in Kuwait. Although our data is comparable with the previous international studies, a higher percentage of bilateral optic nerve, brain, and callosal involvement was observed. Further multicenter studies with a larger cohort are needed to confirm our results.
  • Neurological Consequences of 2019-nCoV Infection: A Comprehensive Literature Review. [Review]
    Cureus. 2020 Jun 24; 12(6):e8790.Azim D, Nasim S, … Patel S
  • First identified in November 2019 in Hubei Province, the coronavirus disease of 2019 (COVID-19) caused by SARS-CoV-2 soon spread worldwide to become a global health pandemic. The COVID-19 preferentially damages the respiratory system that produces symptoms such as fever, cough, and shortness of breath. However, the infection often tends to disseminate to involve various organ systems. Recent evid…
  • Progress Toward Polio Eradication - Worldwide, January 2018-March 2020. [Journal Article]
    MMWR Morb Mortal Wkly Rep. 2020 Jun 26; 69(25):784-789.Chard AN, Datta SD, … Zaffran M
  • Since the Global Polio Eradication Initiative (GPEI) was established in 1988, two of the three wild poliovirus (WPV) serotypes (types 2 and 3) have been eradicated.* Transmission of WPV type 1 (WPV1) remains uninterrupted only in Afghanistan and Pakistan. This report summarizes progress toward global polio eradication during January 1, 2018-March 31, 2020 and updates previous reports (1,2). In 20…
  • Chikungunya encephalitis: report of a fatal case in Northeastern Brazil. [Case Reports]
    Rev Inst Med Trop Sao Paulo. 2020; 62:e40.Lima ECB, Januário AMS, … Lacerda HR
  • Chikungunya, a viral infection that presents with fever, rash and polyarthritis, is usually an acute febrile illness. Uncommon neurological manifestations include meningoencephalitis, encephalitis, myelitis, Guillain-Barre syndrome, myelopathy and neuropathy. During an outbreak of the disease in La Reunion Island, abnormalities were observed in the magnetic resonance imaging (MRI) of patients wit…
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