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29,593 results
  • High mobility group box 1 (HMGB1) protein in multiple sclerosis (MS): Mechanisms and therapeutic potential. [Review]
    Life Sci 2019; :116924Paudel YN, Angelopoulou E, … Othman I
  • Multiple sclerosis (MS) is an autoimmune chronic inflammatory disease with distinctive features of focal demyelination, axonal loss, activation of glial cells, and immune cells infiltration. The precise molecular mechanism underlying the disease progression remains enigmatic despite of the rapid progression on experimental and clinical MS research. The focus of MS therapy relies on the repression…
  • Pathology of inflammatory diseases of the nervous system: Human disease versus animal models. [Review]
    Glia 2019Lassmann H
  • Numerous recent studies have been performed to elucidate the function of microglia, macrophages, and astrocytes in inflammatory diseases of the central nervous system. Regarding myeloid cells a core pattern of activation has been identified, starting with the activation of resident homeostatic microglia followed by recruitment of blood borne myeloid cells. An initial state of proinflammatory acti…
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