Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.
(myofibril myofibrilla)
15,924 results
  • Role of calpains in promoting desmin filaments depolymerization and muscle atrophy. [Review]
    Biochim Biophys Acta Mol Cell Res. 2020 Jun 27 [Online ahead of print]Cohen S
  • Muscle atrophy is an inevitable sequel of fasting, denervation, aging, exposure to microgravity, and many human diseases including, cancer, type-2 diabetes, and renal failure. During atrophy the destruction of the muscle's fundamental contractile machinery, the myofibrils are accelerated leading to a reduction in muscle mass, weakness, frailty, and physical disability. Recent findings indicate th…
  • The dynamics of Ca2+ within the sarcoplasmic reticulum of frog skeletal muscle. A simulation study. [Journal Article]
    J Theor Biol. 2020 Jun 10 [Online ahead of print]Pizarro G, Fernando Olivera J
  • In skeletal muscle, Ca2+ release from the sarcoplasmic reticulum (SR) triggers contraction. In this study we develop a two compartment model to account for the Ca2+ dynamics in frog skeletal muscle fibers. The two compartments in the model correspond to the SR and the cytoplasm, where the myofibrils are placed. We use a detailed model for the several Ca2+ binding proteins in the cytoplasm in line…
  • Telocytes in the Myocardium of Children with Congenital Heart Disease Tetralogy of Fallot. [Journal Article]
    Bull Exp Biol Med. 2020 May; 169(1):137-146.Sukhacheva TV, Nizyaeva NV, … Serov RA
  • Telocytes, a new type of interstitial stem cells with long thin processes that form a three-dimensional network around cardiomyocytes, vessels, and nerve fibers were described in the myocardium of children with tetralogy of Fallot. Two types of morphologically different telocytes, spindle-shaped and rounded, were identified. Contacts of telocytes with stem cells and interstitial macrophages were …
  • Kindlin-2 deficiency induces fatal intestinal obstruction in mice. [Journal Article]
    Theranostics. 2020; 10(14):6182-6200.He X, Song J, … Zhang H
  • CONCLUSIONS: We demonstrated that Kindlin-2 is essential for maintaining the normal structure and function of smooth muscles. Loss of Kindlin-2 impairs smooth muscle formation during embryonic development by inducing apoptosis and jeopardizes the contraction of adult smooth muscle by blocking Ca2+ influx that leads to intestinal obstruction. Mice with Kindlin-2 depletion in adult smooth muscle could be a potent animal model of intestinal obstruction for disease research, drug treatment and prognosis.
  • Hypertrophic cardiomyopathy in myosin-binding protein C (MYBPC3) Icelandic founder mutation carriers. [Journal Article]
    Open Heart. 2020; 7(1):e001220.Adalsteinsdottir B, Burke M, … Gunnarsson GT
  • CONCLUSIONS: Phenotypic expression of the Icelandic MYBPC3 founder mutation varies by age, sex and proband status. Men are more likely to have LVH at a younger age, and disease manifestations were more prominent in probands than in relatives identified via family screening. G+/LVH- individuals had subtle clinical differences from unaffected relatives well into adulthood, indicating subclinical phenotypic expression of the pathogenic mutation.
  • Extraction of Thick Filaments in Individual Sarcomeres Affects Force Production by Single Myofibrils. [Journal Article]
    Biophys J. 2020 Apr 21; 118(8):1921-1929.Mendoza AC, Rassier DE
  • It has been accepted that the force produced by a skeletal muscle myofibril depends on its cross-sectional area but not on the number of active sarcomeres because they are arranged in series. However, a previous study performed by our group showed that blocking actomyosin interactions within an activated myofibril and depleting the thick filaments in one sarcomere unexpectedly reduced force produ…
  • Role of Oxidative Stress in Metabolic and Subcellular Abnormalities in Diabetic Cardiomyopathy. [Review]
    Int J Mol Sci. 2020 Mar 31; 21(7)Dhalla NS, Shah AK, Tappia PS
  • Although the presence of cardiac dysfunction and cardiomyopathy in chronic diabetes has been recognized, the pathophysiology of diabetes-induced metabolic and subcellular changes as well as the therapeutic approaches for the prevention of diabetic cardiomyopathy are not fully understood. Cardiac dysfunction in chronic diabetes has been shown to be associated with Ca2+-handling abnormalities, incr…
New Search Next