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412 results
  • Novel SRF-ICA1L Fusions in Cellular Myoid Neoplasms With Potential For Malignant Behavior. [Journal Article]
    Am J Surg Pathol 2019Suurmeijer AJ, Dickson BC, … Antonescu CR
  • Pericytic tumors comprise a histologic continuum of neoplasms with perivascular myoid differentiation, which includes glomus tumors, myopericytoma, myofibroma, and angioleiomyoma. Despite their morphologic overlap, recent data suggest a dichotomy in their genetic signatures, including recurrent NOTCH gene fusions in glomus tumors and PDGFRB mutations in myofibromas and myopericytomas. Moreover, S…
  • Solitary orbital myofibroma in a child: A rare case report with literature review. [Case Reports]
    Indian J Ophthalmol 2019; 67(7):1240-1245Madhuri BK, Tripathy D, Mittal R
  • Myofibroma is a rare benign mesenchymal tumor of uncertain histogenesis. A six-year-old boy presented with a unilateral lower eyelid mass of six weeks' duration. MRI revealed a circumscribed mass in the inferolateral orbit with bony erosion. A systemic examination was unremarkable. Excision with histopathology revealed a partially infiltrative spindle cell tumor with bland nuclear morphology expr…
  • Spontaneous Radial Nerve Palsy due to an Unrecognized Myofibroma: A Case Report. [Journal Article]
    JBJS Case Connect 2019 Apr-Jun; 9(2):e0284Hinchcliff KM, Rogers J, … Szabo RM
  • CONCLUSIONS: A trial of observation is often indicated in the cases of isolated nerve palsy where anatomic lesions have been eliminated. This case highlights that imaging studies can miss a tumor involving nerve and that painless, spontaneous nerve palsy may be a time where early surgical intervention offers a better chance of recovery.
  • Pericytes in Sarcomas and Other Mesenchymal Tumors. [Journal Article]
    Adv Exp Med Biol 2019; 1147:109-124Chang L, Scott MA, … James AW
  • Tumors of mesenchymal origin are a diverse group, with >130 distinct entities currently recognized by the World Health Organization. A subset of mesenchymal tumors grow or invade in a perivascular fashion, and their potential relationship to pericytes is a matter of ongoing interest. In fact, multiple intersections exist between pericytes and tumors of mesenchymal origin. First, pericytes are the…
  • [Pediatric tumors with spindle cell morphology]. [Review]
    Pathologe 2019; 40(4):381-392Vokuhl C
  • Spindle cell tumors in childhood are rare lesions with a heterogeneous morphological picture and clinical course, ranging from benign lesions to fully malignant tumors. The clinical assessment of these tumors is often challenging since some of them show fast growth dynamics but are utterly benign, while a subset of slow-growing tumors can represent malignant entities. Due to the rarity of these t…
  • Association of PDGFRB Mutations With Pediatric Myofibroma and Myofibromatosis. [Journal Article]
    JAMA Dermatol 2019Dachy G, de Krijger RR, … Demoulin JB
  • CONCLUSIONS: Gain-of-function mutations of PDGFRB in myofibromas may affect only children and be more frequent in the multicentric form of disease, albeit present in solitary pediatric myofibromas. These alterations may be sensitive to tyrosine kinase inhibitors. The PDGFRB sequencing appears to have a high value for diagnosis, prognosis, and therapy of soft-tissue tumors in children.
  • Congenital Granular Cell Epulis: Classic Presentation and Its Differential Diagnosis. [Journal Article]
    Head Neck Pathol 2019Cheung JM, Putra J
  • Congenital granular cell epulis (CGCE) is an uncommon lesion of unclear pathogenesis. It occurs predominantly in female newborns with a predilection site of the maxillary alveolar ridge. The mass enlarges prenatally but the growth arrests after birth. Histologically, CGCE is characterized by a proliferation of polygonal cells with eosinophilic, granular cytoplasm and eccentric, bland-appearing nu…
  • Infantile myofibromatosis treated by mandibulectomy and staged reconstruction with submental flap and free fibula flap: a case report. [Journal Article]
    J Otolaryngol Head Neck Surg 2019; 48(1):14Maby A, Guay B, Thuot F
  • CONCLUSIONS: Mandibular involvement by myofibromatosis is rare, and the extend of bone destruction and reconstruction make this case unique. To our knowledge, this is the only reported case of fibula free flap mandibular reconstruction in a patient with infantile myofibromatosis , as well as one of the youngest reported submental island flaps for any pathology. We describe the clinical presentation and management, including relevant imaging, histopathology, medical and surgical treatment as well as a review of relevant literature.
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