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1,524 results
  • Non-immunogenic utrophin gene therapy for the treatment of muscular dystrophy animal models. [Journal Article]
    Nat Med 2019Song Y, Morales L, … Stedman HH
  • The essential product of the Duchenne muscular dystrophy (DMD) gene is dystrophin1, a rod-like protein2 that protects striated myocytes from contraction-induced injury3,4. Dystrophin-related protein (or utrophin) retains most of the structural and protein binding elements of dystrophin5. Importantly, normal thymic expression in DMD patients6 should protect utrophin by central immunologic toleranc…
  • Clostridium sordellii-associated gas gangrene in eight horses, 1998-2019. [Journal Article]
    J Vet Diagn Invest 2019; :1040638719877844Sacco SC, Ortega J, … Uzal FA
  • Gas gangrene occurs in several animal species and is caused by one or more clostridial species. In horses, the disease is most often caused by Clostridium perfringens type A. Although Clostridium sordellii has been associated with gas gangrene in ruminants and humans, cases of the disease associated with this microorganism have not been described in horses, to our knowledge. We report herein 8 ca…
  • Fatal lancehead pit viper (Bothrops spp.) envenomation in horses. [Journal Article]
    Toxicon 2019; 170:41-50Machado M, Wilson TM, … Botelho de Castro M
  • Snake bite envenomations in farm animals are generally overestimated as the cause of mortality in rural areas in Latin America. However, most cases are based only on anecdotal information and assumptions, and lack diagnostic evidence. There are few proven reports of envenomation and death in horses caused by snakebites from members of the Bothrops genus (lancehead pit vipers). This study presents…
  • Calcific Myonecrosis of the Leg: A Rare Entity. [Case Reports]
    Medicina (Kaunas) 2019; 55(9)Angelini A, Mavrogenis AF, … Ruggieri P
  • Calcific myonecrosis is a rare disease that has been shown to be a late sequela of trauma. This article presents a 68-year-old man with calcific myonecrosis of the leg 40 years after a tibial fracture complicated with peroneal nerve palsy. The soft tissue mass increased in size after another injury to the leg that occurred two years before his presentation. Physical examination at presentation sh…
  • Upper-Limb Diabetic Myonecrosis: Atypical Presentation of a Rare Complication. [Journal Article]
    Am J Case Rep 2019; 20:1268-1272Jalali Z, Sharif SK
  • CONCLUSIONS: Diabetic myonecrosis should be suspected in any poorly controlled diabetic patient presenting with otherwise unexplained muscle pain without any evidence of infection. Diagnosis can be made by MRI, leaving very few indications for invasive procedures. Analgesics and glycemic control are the mainstays of treatment.
  • Myonecrosis: A Rare Complication of Cryoneurolysis. [Journal Article]
    J Emerg Med 2019; 57(3):e73-e76Cahani D, Chacko J, Hahn B
  • Considered a safe and effective procedure, cryoneurolysis has been used to provide pain relief for chronic joint pain for decades. The procedure is similar to common ultrasound-guided percutaneous procedures. Although the literature is limited on the efficacy and safety of cryoneurolysis, there is a consensus that the use of cryoneurolysis is effective, with a risk profile similar to that of othe…
  • Histotoxic Clostridial Infections. [Journal Article]
    Microbiol Spectr 2018; 6(4)Nagahama M, Takehara M, Rood JI
  • The pathogenesis of clostridial myonecrosis or gas gangrene involves an interruption to the blood supply to the infected tissues, often via a traumatic wound, anaerobic growth of the infecting clostridial cells, the production of extracellular toxins, and toxin-mediated cell and tissue damage. This review focuses on host-pathogen interactions in Clostridium perfringens-mediated and Clostridium se…
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