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186,891 results
  • Tertiary lymphoid organs in the inflammatory myopathy associated with PD-1 inhibitors. [Journal Article]
    J Immunother Cancer 2019; 7(1):256Matsubara S, Seki M, … Takamori M
  • CONCLUSIONS: In inflammatory myopathy associated with PD-1 inhibitors, CD8+ cells appear to predominantly destruct muscle fibers. The presence of lymphoid follicle-like structures and expression of PNAd and CCL21 on the endothelial cells suggest the tertiary lymphoid organs are formed, and involved in the leakage of lymphocytes. Thus, in the three cases examined, formation of the tertiary lymphoid organs is likely to play an important role in genesis of the PD-1 myopathy.
  • Creatine as a Candidate to Prevent Statin Myopathy. [Review]
    Biomolecules 2019; 9(9)Balestrino M, Adriano E
  • Statins prevent cardiovascular diseases, yet their use is limited by the muscle disturbances they cause. Rarely, statin-induced myopathy is autoimmune, but more commonly it is due to direct muscle toxicity. Available evidence suggests that statin-induced creatine deficiency might be a major cause of this toxicity, and that creatine supplementation prevents it. Statins inhibit guanidinoacetate met…
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