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370 results
  • Regulation and evolution of muscle development in tunicates. [Review]
    Evodevo 2019; 10:13Razy-Krajka F, Stolfi A
  • For more than a century, studies on tunicate muscle formation have revealed many principles of cell fate specification, gene regulation, morphogenesis, and evolution. Here, we review the key studies that have probed the development of all the various muscle cell types in a wide variety of tunicate species. We seize this occasion to explore the implications and questions raised by these findings i…
  • In Vivo Monitoring of Ca2+ Uptake into Subcellular Compartments of Mouse Skeletal Muscle. [Journal Article]
    Methods Mol Biol 2019; 1925:127-142Rudolf R, Trajanovska S, … Pozzan T
  • Ca2+ regulates many functions of skeletal muscle, including excitation-contraction coupling, energy homeostasis, and fiber-type-specific gene expression. However, microscopic observation of Ca2+ signalling in live skeletal muscle tissue has been hampered, in particular, by the combination of the high speed of Ca2+ transients and the contractile properties that are inherent to muscle. The present …
  • No voltage change at skeletal muscle SR membrane during Ca2+ release-just Mermaids on acid. [Comment]
    J Gen Physiol 2018; 150(8):1055-1058Melzer W
  • Calcium ions control multiple physiological functions by binding to extracellular and intracellular targets. One of the best-studied Ca2+-dependent functions is contraction of smooth and striated muscle tissue, which results from Ca2+ ligation to calmodulin and troponin C, respectively. Ca2+ signaling typically involves flux of the ion across membranes via specifically gated channel proteins. Bec…
  • Afterdepolarizations and triggered activity as a mechanism for clinical arrhythmias. [Review]
    Pacing Clin Electrophysiol 2018Wit AL
  • Afterdepolarizations cause triggered arrhythmias. One kind occurs after repolarization is complete, delayed afterdepolarizations (DADs). Another occurs as an interruption in repolarization, early afterdepolarizations (EADs). Afterdepolarizations initiate arrhythmias when they depolarize membrane potential to threshold potential for triggering action potentials. DADs usually occur mostly when Ca2+…
  • TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility. [Journal Article]
    Biophys J 2018; 114(7):1646-1656Vetter AD, Houang EM, … Metzger JM
  • The heterotrimeric cardiac troponin complex is a key regulator of contraction and plays an essential role in conferring Ca2+ sensitivity to the sarcomere. During ischemic injury, rapidly accumulating protons acidify the myoplasm, resulting in markedly reduced Ca2+ sensitivity of the sarcomere. Unlike the adult heart, sarcomeric Ca2+ sensitivity in fetal cardiac tissue is comparatively pH insensit…
  • A skeletal muscle L-type Ca2+ channel with a mutation in the selectivity filter (CaV1.1 E1014K) conducts K. [Journal Article]
    J Biol Chem 2018; 293(9):3126-3133Beqollari D, Dockstader K, Bannister RA
  • A glutamate-to-lysine substitution at position 1014 within the selectivity filter of the skeletal muscle L-type Ca2+ channel (CaV1.1) abolishes Ca2+ flux through the channel pore. Mice engineered to exclusively express the mutant channel display accelerated muscle fatigue, changes in muscle composition, and altered metabolism relative to wildtype littermates. By contrast, mice expressing another …
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