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481 results
  • Naphthalene, a versatile platform in medicinal chemistry: Sky-high perspective. [Review]
    Eur J Med Chem 2019; 161:252-276Makar S, Saha T, Singh SK
  • Naphthalene, a cytotoxic moiety, is an extensively explored aromatic conjugated system with applications in various pathophysiological conditions viz. anticancer, antimicrobial, anti-inflammatory, antiviral, antitubercular, antihypertensive, antidiabetic, anti-neurodegenerative, antipsychotic, anticonvulsant, antidepressant. Naphthalene epoxides and naphthoquinones are most reactive metabolites o…
  • The Importance of the Structural Similarity of Drugs Used for Depression and Inflammation, Two Comorbid Diseases. [Review]
    Curr Top Med Chem 2018; 18(16):1416-1421Bayram FEÖ, Reis R, … Sipahi H
  • Growing evidence links inflammation to depression and the combination of antiinflammatory drugs with an antidepressant to treat depressive symptoms is currently suggested. There are only few studies concerning the molecular mechanism underlying this comorbidity, and many of them point out the importance of the tryptophan pathway. There is yet no data that analyzes the structural similarity of the…
  • Crystal structure of phospholipase A2 in complex with 1-naphthaleneacetic acid. [Journal Article]
    IUBMB Life 2018; 70(10):995-1001Dileep KV, Remya C, … Sadasivan C
  • Phospholipase A2 (PLA2) is one of the rate limiting enzymes involved in the production of arachidonic acid, a potent inflammatory mediator. PLA2 is widely distributed all over the animal kingdom. It is also seen in inflammatory exudation and venoms of different organisms. The studies demonstrated that PLA2 inhibitors have broad spectrum activities that they can either be used against inflammation…
  • Probing the Interplay between Amorphous Solid Dispersion Stability and Polymer Functionality. [Journal Article]
    Mol Pharm 2018; 15(7):2714-2720Frank DS, Matzger AJ
  • Amorphous solid dispersions containing a polymeric component often impart improved stability against crystallization for a small molecule relative to the pure amorphous form. However, the relationship between side chain functionalities on a polymer and the ability of a polymer to stabilize against crystallization is not well understood. To shed light on this relationship, a series of polymers wer…
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