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(nalbuphine)
999 results
  • Organophotocatalytic N-Demethylation of Oxycodone using Molecular Oxygen. [Journal Article]
    Chemistry 2020Chen Y, Glotz G, … Kappe CO
  • N -Demethylation of oxycodone is one of the key steps in synthesis of important opioid antagonists like naloxone or analgesics like nalbuphine. The reaction is typically carried out using stoichiometric amounts of toxic and corrosive reagents. Herein we present a green and scalable organophotocatalytic procedure that accomplishes the N -demethylation step using molecular oxygen as the terminal ox…
  • Local Wound Infiltration with Ropivacaine for Postoperative Pain Control in Caesarean Section. [Journal Article]
    Cureus 2019; 11(9):e5572Nasir F, Sohail I, … Habib M
  • Background The rate of the caesarean section has been on a progressive rise ever since its association with improved fetal prognosis was established. This study was conducted to assess the effect of local wound infiltration with ropivacaine on the postoperative analgesia requirement and pain scores in caesarean section patients. Methods This was a prospective single-blinded randomized control tri…
  • A dual system platform for drug metabolism: Nalbuphine as a model compound. [Journal Article]
    Eur J Pharm Sci 2020; 141:105093Liang RJ, Shih YN, … Wang HJ
  • Reaction phenotyping is a method commonly used for characterizing drug metabolism. It determines the drug metabolic pathways and ratios by measuring the metabolized fractions of individual enzymes. However, currently published results have focused on cytochrome P450s (CYPs), while not considering phase II metabolism. Therefore, the morphinan analgesic, nalbuphine, primarily metabolized in the liv…
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