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5,184 results
  • Proteomic signatures of brain regions affected by tau pathology in early and late stages of Alzheimer's disease. [Journal Article]
  • NDNeurobiol Dis 2019 Jun 14; :104509
  • Mendonça CF, Kuras M, … Rezeli M
  • CONCLUSIONS: This work provides the comparison of proteomic changes in brain regions affected by tau pathology at different stages of AD. Although we identified commonly regulated proteins and pathways during disease advancement, we found that the dysregulated processes are predominantly region specific. In addition, a distinct proteomic signature was found between MTL and neocortex in healthy subjects that might be related to AD vulnerability. These findings highlight the need for investigating AD's cascade of events throughout the whole brain and studies spanning more brain areas are required to better understand AD etiology and region vulnerability to disease.
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