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5,321 results
  • Side-Chain Protonation States of a Fluorescent Arginine. [Journal Article]
    J Org Chem 2019Marshall SR, Stoudt ML, … Allen WE
  • An arginine derivative with a fluorescent side-chain, Boc-Arg(Nap)-OH, was prepared by palladium(0)-catalyzed coupling of Boc-Arg-OH with a 4-bromonaphthalimide. The presence of the fluorophore lowers the pKa of the side-chain guanidinium group by several orders of magnitude, to 9.0 (± 0.1), allowing the derivative to access an electrically neutral protonation state that is not generally availabl…
  • Closed-loop acoustic stimulation enhances sleep oscillations but not memory performance. [Journal Article]
    eNeuro 2019Henin S, Borges H, … Liu A
  • Slow-oscillations and spindle activity during non-REM sleep have been implicated in memory consolidation. Closed-loop acoustic stimulation has previously been shown to enhance slow oscillations and spindle activity during sleep and improve verbal associative memory. We assessed the effect of closed-loop acoustic stimulation during a daytime nap on a virtual reality spatial navigation task in 12 h…
  • A clonal expression biomarker associates with lung cancer mortality. [Journal Article]
    Nat Med 2019Biswas D, Birkbak NJ, … TRACERx Consortium
  • An aim of molecular biomarkers is to stratify patients with cancer into disease subtypes predictive of outcome, improving diagnostic precision beyond clinical descriptors such as tumor stage1. Transcriptomic intratumor heterogeneity (RNA-ITH) has been shown to confound existing expression-based biomarkers across multiple cancer types2-6. Here, we analyze multi-region whole-exome and RNA sequencin…
  • Sleep preserves subjective and sympathetic emotional response of memories. [Journal Article]
    Neurobiol Learn Mem 2019; 166:107096Jones BJ, Spencer RMC
  • Sleep consolidates episodic content of emotional memories. Whether it likewise preserves or, to the contrary, depotentiates the emotional response associated with memory content is unclear, as there is conflicting evidence. In the current study, we investigated the influence of an afternoon nap (2-hr nap opportunity) on emotional responses of memories using multiple simultaneous measures. Young a…
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