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(narcolepsy)
5,468 results
  • Children with Narcolepsy type 1 have increased T-cell responses to orexins. [Journal Article]
    Ann Clin Transl Neurol 2019Cogswell AC, Maski K, … Koralnik IJ
  • Narcolepsy type 1 (NT1) is caused by severe loss of the orexin neurons, and is highly associated with HLA DQB1*06:02. Using intracellular cytokine staining, we observed a higher frequency of IFN-γ- and TNF-α-producing CD4+ and CD8+ T-cells in response to orexins in 27 children with NT1 compared to 15 healthy control children. Conversely, no such difference was observed between 14 NT1 and 16 HC ad…
  • Psychopharmacology of sleep disorders. [Journal Article]
    Handb Clin Neurol 2019; 165:345-364Singh B, McArdle N, Hillman D
  • The concept of psychopharmacology has particular applicability to the study of sleep because the states of sleep and wake are so intensely and complexly neurophysiologic in nature. Growing understanding of the structure and function of the neural pathways involved is increasing the capacity to devise targeted pharmacologic interventions to address maladaptions and malfunctions that result in vari…
  • Treatment of Excessive Daytime Sleepiness in Patients with Narcolepsy. [Review]
    Curr Treat Options Neurol 2019; 21(11):57Pérez-Carbonell L
  • The aim of this review is to discuss and summarize the main therapeutic strategies for the management of excessive daytime sleepiness (EDS) in patients with narcolepsy. An overview of novel therapies and potential future options are covered as well.
  • Orexins as Novel Therapeutic Targets in Inflammatory and Neurodegenerative Diseases. [Review]
    Front Endocrinol (Lausanne) 2019; 10:709Couvineau A, Voisin T, … Tan YV
  • Orexins [orexin-A (OXA) and orexin-B (OXB)] are two isoforms of neuropeptides produced by the hypothalamus. The main biological actions of orexins, focused on the central nervous system, are to control the sleep/wake process, appetite and feeding, energy homeostasis, drug addiction, and cognitive processes. These effects are mediated by two G protein-coupled receptor (GPCR) subtypes named OX1R an…
  • A 10-Year Longitudinal Observational Study Of Cataplexy In A Cohort Of Narcolepsy Type 1 Patients. [Journal Article]
    Nat Sci Sleep 2019; 11:231-239Almeneessier AS, Alballa NS, … BaHammam AS
  • CONCLUSIONS: The findings suggest that the course of NT1 is not stable. Over a 10-year period, cataplexy symptoms improved or disappeared in a large proportion of patients, and there was an improvement in daytime sleepiness and nighttime sleep quality. More prospective studies that repeatedly monitor CSF-HCRT are needed to confirm the current findings.
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