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(natural herbal products)
2,792 results
  • The Redox Role of G6PD in Cell Growth, Cell Death, and Cancer. [Review]
    Cells 2019; 8(9)Yang HC, Wu YH, … Chiu DT
  • The generation of reducing equivalent NADPH via glucose-6-phosphate dehydrogenase (G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in cells. NADPH also plays key roles in cellular processes mediated by redox signaling. Insufficient G6PD activity predisposes cells to growth retardation and demise. Severely lacking G6PD impairs embryonic development and delays …
  • Genus Miliusa: A Review of Phytochemistry and Pharmacology. [Review]
    Evid Based Complement Alternat Med 2019; 2019:8314693The Son N
  • CONCLUSIONS: A vast amount of data showed that genus Miliusa contained various classes of secondary metabolites. Herein, more than two hundred constituents were isolated, comprising alkaloids, geranylated homogentisic acids, flavonoids, lignans, neolignans, terpenoids, acetogenins, styryls, lactones, phenolics, amides, alcohols, and furfural derivatives. Novel miliusanes and bicyclic lactones have been remarkable characteristics of Miliusa plants. Essential oils from these plants were also detected, with a high amount of β-caryophyllene. Numerous in vitro biological researches on, for example, anticancer, antifungal, antimycobacterial, anti-inflammation, and cardiac activity, especially in terms of cytotoxicity, using either isolated compounds or plant extracts, implied that Miliusa phytochemical components now set out to have a key role in pharmacological development. M. smithiae ethyl acetate extract and its flavonoid ayanin (75) inhibited the growth of MCF-7 cell line comparable with positive control ellipticine. (+)-Miliusol (72) stimulated in vivo anticancer experiment against HCT116 xenograft mouse tumor following the p21-dependent induction of cellular senescence mechanism.
  • Melissa officinalis ssp. altissima extracts: A therapeutic approach targeting psoriasis in mice. [Journal Article]
    J Ethnopharmacol 2019; 246:112208Dimitris D, Ekaterina-Michaela T, … Helen S
  • CONCLUSIONS: The triterpene derivatives of the dichloromethane extract are likely to be responsible for its anti-psoriatic activity. The abundant polyphenolic load of the decoction contributes to its high antioxidant activity and the most effective results against psoriasis. The anti-psoriatic activity of the decoction confirmed the traditional use of this plant as antioxidant, wound healing and skin barrier repair agent.
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