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6,168 results
  • Inappropriate antidiuretic hormone secretion in amyotrophic lateral sclerosis. [Journal Article]
    Clin Neuropathol. 2020 May 25 [Online ahead of print]Douglas A, Baborie A
  • Only a few cases of syndrome of inappropriate antidiuretic hormone secretion (SIADH) in the setting of amyotrophic lateral sclerosis (ALS) have been described in the literature. We present the case of an 81-year-old male who developed severe hyponatremia following elective total hip replacement. His past medical history included prostate cancer, which was under surveillance, and ischemic heart di…
  • The effects of acetylcholinesterase inhibitors on morbidity after general anesthesia and surgery. [Review]
    Neuropharmacology. 2020 May 19; 173:108134.Shaydenfish D, Wongtangman K, … Schaefer MS
  • Non-depolarizing neuromuscular blocking agents are used during general anesthesia to facilitate intubation and optimize surgical conditions. When patients leave the operating room after surgery, postoperative residual neuromuscular block occurs frequently, increasing vulnerability to respiratory complications such as hypoxemia and unplanned postoperative mechanical ventilation. To restore neuromu…
  • A Neonate With MuSK Congenital Myasthenic Syndrome Presenting With Refractory Respiratory Failure. [Case Reports]
    Front Pediatr. 2020; 8:166.Shen Y, Wang B, … Hei M
  • This was a Chinese neonatal congenital myasthenic syndromes case caused by muscle skeletal receptor tyrosine kinase gene mutations, which have not been recorded in the Human Gene Mutation Database. The newborn girl had refractory respiratory failure from birth to death, and failed extubation seven times. She had two heterozygous mutations: a non-sense mutation c.2062C>T (p.Q688X) inherited from f…
  • Myasthenia gravis and sugammadex: A case report and review of the literature. [Case Reports]
    Saudi J Anaesth. 2020 Apr-Jun; 14(2):244-248.Dontukurthy S, Wisler C, … Tobias JD
  • Anesthesia care during surgical procedures in patients with myasthenia gravis (MG) can be challenging, as these patients have increased sensitivity to neuromuscular blocking agents (NMBAs) and may be at high risk for postoperative weakness and respiratory failure. Even intermediate-acting NMBAs may have a prolonged effect resulting in residual weakness after reversal with acetylcholinesterase inh…
  • Effects of Chaihu-Shugan-San on Small Intestinal Interstitial Cells of Cajal in Mice. [Journal Article]
    Biol Pharm Bull. 2020; 43(4):707-715.Hwang M, Kim JN, … Kim BJ
  • Chaihu-Shugan-San (CSS) has been widely used as an alternative treatment for gastrointestinal (GI) diseases in East Asia. Interstitial cells of Cajal (ICCs) are pacemakers in the GI tract. In the present study, we examined the action of CSS on pacemaker potentials in cultured ICCs from the mouse small intestine in vitro and on GI motility in vivo. We used the electrophysiological methods to measu…
  • Neuromuscular Blockade Agents Reversal with Sugammadex Compared to Neostigmine in the Living Kidney Donors. [Journal Article]
    Open Access Maced J Med Sci. 2019 Dec 30; 7(24):4420-4425.Quang TL, Thu HNT, … Toi CD
  • CONCLUSIONS: The muscle relaxation reversal effect of sugammadex was faster than that of neostigmine, the duration TOF ≥ 0.9 and the time to extubation was significantly faster. Sugammadex did not cause hemodynamic changes before and after muscle relaxation reversal, neostigmine resulted in the bradycardia, increased phlegm secreting and other side effects. The renal function after 24 hours postoperatively of two groups was similar.
  • SUGAMMADEX versus neostigmine after ROCURONIUM continuous infusion in patients undergoing liver transplantation. [Journal Article]
    BMC Anesthesiol. 2020 Mar 25; 20(1):70.Deana C, Barbariol F, … Rocca GD
  • CONCLUSIONS: Sugammadex is able to reverse neuromuscular block maintained by rocuronium continuous infusion in patients undergoing liver transplantation. The mean reversal time obtained with sugammadex was significantly faster than that for neostigmine. It is important to note that the sugammadex recovery time in this population was found to be considerably longer than in other surgical settings, and should be considered in clinical practice.
  • Association of neuromuscular reversal by sugammadex and neostigmine with 90-day mortality after non-cardiac surgery. [Journal Article]
    BMC Anesthesiol. 2020 02 20; 20(1):41.Oh TK, Ryu JH, … Oh AY
  • CONCLUSIONS: This retrospective cohort study suggested that reversing rocuronium with sugammadex might be associated with lower 90-day mortality after non-cardiac surgery compared to neostigmine. However, since this study did not evaluate quantitative neuromuscular function in the postoperative period due to its retrospective design, the results should be interpreted carefully. Future prospective studies with quantitative neuromuscular monitoring in the postoperative period should be performed to confirm these results.
  • Report of a case of necrotizing autoimmune myopathy with thymoma-associated myasthenia gravis. [Journal Article]
    Int J Neurosci. 2020 Feb 19 [Online ahead of print]Huang G, Zhou X, Yao D
  • Purpose: Myasthenia gravis (MG) is an autoimmune disease and closely related to thymoma. Inflammatory myopathy may accompany with other autoimmune diseases. However, concurrence of inflammatory myopathy and MG is very rare. Necrotizing autoimmune myopathy (NAM), a rare form of inflammatory myopathy, is characterized by necrosis and regeneration of myocytes in proximal muscles without significant…
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