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80,284 results
  • PD-1hi CXCR5- T peripheral helper cells promote B cells responses in lupus via MAF and IL-21. [Journal Article]
    JCI Insight 2019Bocharnikov AV, Keegan J, … Rao DA
  • Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by pathologic T cell-B cell interactions and autoantibody production. Defining the T cell populations that drive B cell responses in SLE may enable design of therapies that specifically target pathologic cell subsets. Here we evaluated the phenotypes of CD4+ T cells in the circulation of 52 SLE patients drawn from multiple …
  • The number of nephrons in different glomerular diseases. [Journal Article]
    PeerJ 2019; 7:e7640Viggiano D, Nigro M, … Capasso G
  • The total number of nephrons has been measured mainly from post-mortem studies and only in selected populations. Data from living subjects are scanty, and direct comparisons among different glomerular diseases are lacking. The present work exploits modern methodology to estimate the total nephron number in glomerulopathies with prevalent proteinuria/nephrotic syndrome versus glomerulopathies with…
  • Urinary Neuropilin-1: A Predictive Biomarker for Renal Outcome in Lupus Nephritis. [Journal Article]
    Int J Mol Sci 2019; 20(18)Torres-Salido MT, Sanchis M, … Cortés-Hernández J
  • At present, Lupus Nephritis (LN) is still awaiting a biomarker to better monitor disease activity, guide clinical treatment, and predict a patient's long-term outcome. In the last decade, novel biomarkers have been identified to monitor the disease, but none have been incorporated into clinical practice. The transmembrane receptor neuropilin-1 (NRP-1) is highly expressed by mesangial cells and it…
  • Concurrent Anti-glomerular Basement Membrane Nephritis and IgA Nephropathy. [Journal Article]
    J Pathol Transl Med 2019Suh KS, Choi SY, … Yeo MK
  • Anti-glomerular basement membrane (GBM) nephritis is characterized by circulating anti-GBM antibodies and crescentic glomerulonephritis (GN) with deposition of immunoglobulin (Ig) G along the GBM. In a limited number of cases, glomerular immune complexes have been identified in anti-GBM nephritis. A 38-year-old female presented azotemia, hematuria, and proteinuria without any pulmonary symptoms. …
  • Acute kidney injury in hematopoietic stem cell transplantation. [Journal Article]
    Curr Opin Crit Care 2019Wanchoo R, Stotter BR, … Jhaveri KD
  • Acute kidney injury (AKI) in the setting of hematopoietic stem cell transplantation (HSCT) is common in pediatric and adult patients. The incidence ranges from 12 to 66%, and development of AKI in the posttransplant course is independently associated with higher mortality.
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