- [Simulation of the disease caused by Hantaan virus in white mice by a complex of virological, biochemical, and hematological parameters]. [Journal Article]
- VVVopr Virusol 2008 Sep-Oct; 53(5):41-5
- The essence of studies was that the disease is simulated in 12-day albino mice subcutaneously infected with Hantaan virus, strain 76-118 in a dose of 10 LD50. As an efficiency index, the study of dru…
The essence of studies was that the disease is simulated in 12-day albino mice subcutaneously infected with Hantaan virus, strain 76-118 in a dose of 10 LD50. As an efficiency index, the study of drugs uses major (death protection coefficient, mean animal lifetime) and auxiliary (virological: pathogen accumulation in the brain tissues of deceased animals) parameters, biochemical (the levels of creatinine, urea, alanine aminotransferase, aspartate aminotransferase, malonic dialdehyde), hematological (count of leukocytes, leukogram) ones; as well as interferon status (the levels of circulatory interferon, leukocytic production of alpha- and gamma-interferons). The procedure for simulating the disease caused by Hantaan virus on an experimental animal is used to choose effective drugs against the pathogen of hemorrhagic nephrosonephritis.
- [Nephrotic crisis in children]. [Journal Article]
- UUrologiia 1999 Nov-Dec; (6):18-20
- The aim of the study was elucidation of diagnostic criteria of the nephrotic crisis in children with primary and secondary nephrosonephritis. 44 children with nephrotic crisis (59% of them had primar…
The aim of the study was elucidation of diagnostic criteria of the nephrotic crisis in children with primary and secondary nephrosonephritis. 44 children with nephrotic crisis (59% of them had primary glomerulonephritis, 41% - secondary one) and 62 control patients with activity of nephrotic syndrome of the third degree were examined. The tested criteria were the following: the activity of the pathological process, intensity of proteinuria, level of proteinemia, albuminemia and total pool of medium mass molecules in the serum, presence of acute renal failure, diffuse cavitary edema, abdominal syndrome, migrating erycepalas-like erythemas, severe hypovolemia, thrombotic complications. The analysis of the findings show that a nephrotic crisis reflects highly active nephrosonephritis provoked by different factors including primarily hormone resistance and discontinuation of basic medication. The crisis in children is characterized by variability of the clinical picture including abdominal, hypovolemic, thrombotic, kinin and mixed variants. Early diagnostic criteria of the nephrotic crisis include the level of hypoalbuminemia, hypoproteinemia, low rate ofglomerular filtration, small volume of circulating blood and cardiac output.
- [Hemorrhagic fever with renal syndrome: historical aspects]. [Historical Article]
- UUisahak 2004; 13(1):37-61
- A mysterious disease was first reported from Korea when it had been observed during late spring 1951 in UN Forces operating in the central area close to the 38th parallel. The disease showed distinct…
A mysterious disease was first reported from Korea when it had been observed during late spring 1951 in UN Forces operating in the central area close to the 38th parallel. The disease showed distinctive features which included high fever, low blood pressure, hemorrhagic tendency and acute renal failure. Historically it was apparently a similar disease to a clinical entity designated as Epidemic hemorrhagic fever in Manchuria or Hemorrhagic nephrosonephritis in Far Eastern Russia. After Lee Ho-Wang succeeded in demonstrating Hantaan virus which caused hemorrhagic fever with renal syndrome (HFRS), many studies has revealed various biological and epidemiological aspects of the disease. But the origin of the disease in Korea still remains unknown. This article tests some hypotheses which explain the origin of the disease and reviews the relation between the Korean War and HFRS. It is concluded that the emerging of HFRS would be closely related with the establishment of the munitions supply network in early 1951 in Chinese troop.
- [Hemorrhagic fever with renal syndrome in Croatia--historical review]. [Historical Article]
- AMActa Med Croatica 2003; 57(5):387-92
- Hemorrhagic fever with renal syndrome (HFRS) has been known from ancient times as a disease with many names, which raised great interest during the Korean war (1951-1954), occurring as a large epidem…
Hemorrhagic fever with renal syndrome (HFRS) has been known from ancient times as a disease with many names, which raised great interest during the Korean war (1951-1954), occurring as a large epidemic (Korean hemorrhagic fever). Therefore, the subsequently discovered causative agent was named after the Hantaan River which runs along the 38th parallel and divides North Korea from South Korea. A similar disease was described in 1934 in Scandinavian countries (epidemic nephrosonephritis or nephropathy). During the Second World War, the disease was also registered as wartime nephritis in several European south-eastern countries. Since 1982, similar clinical manifestations of the disease, differently named in various parts of the world, have been assigned one unique name--hemorrhagic fever with renal syndrome, as recommended by the World Health Organization. In Croatia, the first patient with HFRS was diagnosed in 1952 and the paper describing the case was published in 1954 (Radosevic and Mohacek). Since then, the disease has been regularly occurring in our country, especially in sporadic form, with only two smaller epidemics recorded until 1995. The first epidemic with 14 forestry workers involved occurred in 1967 at the Plitvice Lakes, and the second with the same number of soldiers in 1989 around the Pieso-Airport near Zagreb. Simultaneously, in 1967 and 1989 two large-scale epidemics of HFRS occurred in Bosnia and Herzegovina with 144 cases each. Until the first large epidemic of HFRS in Croatia during the Croatian War in 1995, occurring at several localities (Mala Kapela, Dinara mountain, west Slavonia), it was considered that there were only several natural foci of the disease in Croatia (around Ogulin and Slunj, Plitvice Lakes, Zagreb surroundings). A total of 125 cases were reported to the Croatian National Institute of Public Health in 1995. Fifty patients, 45 of them soldiers, were hospitalized at Dr. Fran Mihaljević University Hospital for infectious Diseases in Zagreb. In the same year, the largest epidemic also occurred in Bosnia and Herzegovina with more than 300 cases. During the almost 50-year experience in HFRS surveillance, we have noticed two different clinical manifestations of the disease. The milder type of illness without hemorrhage is more common than the severe type with hemorrhages and extensive renal insufficiency. After the virus discovery and introduction of serologic testing, two causative agents have been detected during the 1970s and 1980s--Vranica and Fojnica, that were later serotyped as Puumala and Dobrava viruses.
- Disseminated intravascular coagulation in Korean hemorrhagic fever. [Journal Article]
- BHBibl Haematol 1983; (49):181-99
- To investigate the nature and role of coagulation and complement alterations in the pathogenesis of Korean hemorrhagic fever (KHF), the profiles from the early stages in 27 male patients were seriall…
To investigate the nature and role of coagulation and complement alterations in the pathogenesis of Korean hemorrhagic fever (KHF), the profiles from the early stages in 27 male patients were serially evaluated. Evidence of disseminated intravascular coagulation (DIC) was observed in 14 of the 27 patients (51.8%) sometime during the course of the disease. The earlier the coagulation tests were performed, the more frequently the evidence of DIC was found. The mean serum C3 concentration was significantly decreased during the early stages, while serum C4 concentrations revealed no significant variation. A significant decrease of the serum C3 concentration, however, was found only in the group with DIC. Korean hemorrhagic fever (KHF) is an acute, systemic disease characterized by fever, hemorrhagic manifestations, and renal failure. This disease has been known to occur from the Pacific Ocean to the Baltic Sea under various synonyms and toponyms including epidemic hemorrhagic fever, hemorrhagic nephrosonephritis and hemorrhagic fever with renal syndrome. Recent investigations demonstrated the identity of these conditions described from Korea, the Soviet Union, Japan, and China. Nephropathia epidemica of Scandinavia was also revealed to have a close serological relation to this disease, but with antigenic differences. The etiologic agent was identified in 1978 by Lee et al., who isolated a viral antigen from a field mouse, Apodemus agrarius coreae, which is the natural reservoir of this disease in Korea. The KHF or Hantaan virus has been propagated in cell cultures and observed electronmicroscopically. In thin sections, the virus was detected within the cytoplasmic granular matrices (viroplasms) of the infected cells. Virus particles were spherical and had an extremely electron-dense core. Negative-contrast staining showed that the virus had an icosahedral structure and annular surface capsomeres. The morphology and morphogenesis of the virus were similar to those of the orbiviruses. The characteristic pathologic findings observed in fatal cases of KHF are congestion and hemorrhage of the renal medulla, hemorrhage in the right atrial wall of the heart, and hemorrhage and necrosis in the anterior lobe of the pituitary gland. The microscopic characteristics of these lesions consist of hemorrhage, coagulation necrosis, and mononuclear cell infiltration. The clinical course of typical KHF may be divided into five phases, each designated for a characteristic physiologic aberration; febrile, hypotensive, oliguric, diuretic, and convalescent.(ABSTRACT TRUNCATED AT 400 WORDS)
- [State of the kidneys of female CBA mice and their progeny following administration of serum and lymphoid cells of syngeneic donors with experimental nephroso-nephritis]. [Journal Article]
- OOntogenez 1980; 11(4):378-85
- The state of kidneys was examined in the mice--recipients of blood serum and lymphoid cells from syngeneic mice-donars with experimental nephrosonephritis. The state of kidneys was also analyzed in t…
The state of kidneys was examined in the mice--recipients of blood serum and lymphoid cells from syngeneic mice-donars with experimental nephrosonephritis. The state of kidneys was also analyzed in the progeny (newborn and 3 months old mice) of females-recipients. Injuries of kidneys were noted in the adult mice-recipients (under the influence of antikidney antibodies and lymphoid cells sensibilized to the kidney antigen) and in their progeny. A suggestion is put forward on the role of immune factors (humoral and cellular) in the "transmission" of nephropathic activity in the system mother--foetus.
- Failure to prove arenavirus infection among the small mammals from an endemic area of Korean hemorrhagic nephrosonephritis. [Journal Article]
- JJJpn J Med Sci Biol 1976; 29(4):187-97
- In the light of recent knowledge on a complex of diseases caused by a new group of viruses, arenaviruses, virological studies largely directed toward small field mammals were undertaken during 1973-1…
In the light of recent knowledge on a complex of diseases caused by a new group of viruses, arenaviruses, virological studies largely directed toward small field mammals were undertaken during 1973-1974 aiming at etiological clarification of Korean hemorrhagic nephrosonephritis (KHNN). Specimens were collected in an endemic area of KHNN located north to northeast of Seoul. Virus isolation tests with 299 urine specimens and 131 mite pools recovered from small mammals and 14 acute stage sera from typical cases yielded negative results. Complement-fixation (CF) tests failed to detect antibodies against the antigens of Congo, lymphocytic choriomeningitis (LCM), Tacaribe, and Pichinde viruses among 366 small mammal sera. In addition, CF tests of 59 of the above sera against Apoi and Lassa virus antigens were negative. The results do not support the likelihood of an arenavirus being transmitted among Korean small field mammals, the overwhelming majority of which were Apodemus agrarius. A hypothesis that KHNN is caused by a virus of small field mammal origin was not proved within the technical limit of relatively unsophisticated methods employed herein.
- [Some data on the clinical picture of hemorrhagic nephrosonephritis]. [Journal Article]
- VMVoen Med Zh 1971; 9:50-1
- [Intravenous emetine in various viral diseases, including Argentine hemorrhagic fever and hemorrhagic nephrosonephritis]. [Journal Article]
- PMPrensa Med Argent 1971; 58(23):1214-8
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- [On the use of extracorporeal hemodialysis in the combined treatment of acute kidney insufficiency in hemorrhagic nephrosonephritis]. [Journal Article]
- TATer Arkh 1966; 39(12):97-100