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617,596 results
  • High-dose conformal proton therapy for clinical perineural invasion in cutaneous head and neck cancer. [Review]
    Oral Oncol 2019; 100:104486Holtzman AL, Mendenhall WM
  • Non-melanomatous skin cancer (NMSC) is the most common malignancy worldwide. Perineural invasion (PNI) is an uncommon (<5%), high-risk feature observed with NMSC more commonly seen in those with squamous cell carcinoma. One-third of these patients will have clinical PNI, which refers to tumor cell invasion extensive enough to cause clinically detectable deficits of the involved nerve. Uncontrolle…
  • Vagotomy influences the lung response to adrenergic agonists and muscarinic antagonists. [Journal Article]
    Respir Physiol Neurobiol 2019; :103358Lourenço LO, Ramos Lopes AC, … Soncini R
  • Mammals airways are extensively innervated by the vagus nerve, which controls the airway diameter and bronchial tone. However, very few studies described the respiratory function and lung morphology after vagal section. In the present study, we evaluated the respiratory mechanics after aerosolization of vehicle (to obtain control values), a muscarinic agonist (methacholine), a β2-adrenergic agoni…
  • LSP5-2157 a new inhibitor of vesicular glutamate transporters. [Journal Article]
    Neuropharmacology 2019; :107902Poirel O, Mamer LE, … Pietrancosta N
  • Vesicular glutamate transporters (VGLUT1-3) mediate the uptake of glutamate into synaptic vesicles. VGLUTs are pivotal actors of excitatory transmission and of almost all brain functions. Their implication in various pathologies has been clearly documented. Despite their functional importance, the pharmacology of VGLUTs is limited to a few dyes such as Trypan Blue, Rose Bengal or Brilliant Yellow…
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