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20,724 results
  • Neuraminidase-3 Is a Negative Regulator of LFA-1 Adhesion. [Journal Article]
    Front Chem 2019; 7:791Howlader MA, Li C, … Cairo CW
  • Within the plasma membrane environment, glycoconjugate-receptor interactions play an important role in the regulation of cell-cell interactions. We have investigated the mechanism and activity of the human neuraminidase (NEU) isoenzyme, NEU3, on T cell adhesion receptors. The enzyme is known to prefer glycolipid substrates, and we confirmed that exogenous enzyme altered the glycolipid composition…
  • Influenza's Newest Trick. [Journal Article]
    MBio 2019; 10(6)Taubenberger JK
  • Influenza A viruses are important pathogens for humans and for many birds and mammals. Hemagglutinin and neuraminidase are the major surface proteins of this enveloped RNA virus. Hemagglutinin requires proteolytic cleavage for activation, but because the viral genome does not encode its own protease, an exogenous serine protease must be provided by host cells. A novel, neuraminidase-dependent mec…
  • The evolution and genetic diversity of avian influenza A(H9N2) viruses in Cambodia, 2015 - 2016. [Journal Article]
    PLoS One 2019; 14(12):e0225428Suttie A, Tok S, … Horwood PF
  • Low pathogenic A(H9N2) subtype avian influenza viruses (AIVs) were originally detected in Cambodian poultry in 2013, and now circulate endemically. We sequenced and characterised 64 A(H9N2) AIVs detected in Cambodian poultry (chickens and ducks) from January 2015 to May 2016. All A(H9) viruses collected in 2015 and 2016 belonged to a new BJ/94-like h9-4.2.5 sub-lineage that emerged in the region …
  • Directed Evolution of a Remarkably Efficient Kdnase from a Bacterial Neuraminidase. [Journal Article]
    Glycobiology 2019Abadi SSK, Deen MC, … Bennet AJ
  • N-acetylneuraminic acid (5-acetamido-3,5-dideoxy-d-glycero-d-galacto-non-2-ulosonic acid), which is the principal sialic acid family member of the non-2-ulosonic acids and their various derivatives, is often found at the terminal position on the glycan chains that adorn all vertebrate cells. This terminal position combined with subtle variations in structure and linkage to the underlying glycan c…
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