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(neuraxon neuraxone)
98,728 results
  • The role of chromatin remodeling complexes in Schwann cell development. [Journal Article]
    Glia 2019Fröb F, Wegner M
  • Schwann cells develop from neural crest cells in an ordered series of events and give rise to myelinating and nonmyelinating subtypes. In their mature state, myelinating Schwann cells produce myelin sheaths that provide trophic support to axons and allow saltatory conduction in the vertebrate peripheral nervous system. Each step of Schwann cell development requires defined changes in chromatin st…
  • FGF10 regulates thalamocortical axon guidance in the developing thalamus. [Journal Article]
    Neurosci Lett 2019; :134685Liu K, Lv Z, … Liu F
  • Thalamocortical axons (TCAs) transmit sensory information to the neocortex by responding to a variety of guidance cues in the environment. Similar to classical guidance cues (ephrins, slits, semaphorins and netrins), morphogens of FGFs can also help axons navigate to their targets. Here, expression analyses reveal that FGF10 is expressed in the chick prethalamus during the navigation of TCAs. The…
  • Axon-like protrusions promote small cell lung cancer migration and metastasis. [Journal Article]
    Elife 2019; 8Yang D, Qu F, … Sage J
  • Metastasis is the main cause of death in cancer patients but remains a poorly understood process. Small cell lung cancer (SCLC) is one of the most lethal and most metastatic cancer types. SCLC cells normally express neuroendocrine and neuronal gene programs but accumulating evidence indicates that these cancer cells become relatively more neuronal and less neuroendocrine as they gain the ability …
  • Quantifying regeneration in patients following peripheral nerve injury. [Review]
    J Plast Reconstr Aesthet Surg 2019Rayner MLD, Brown HL, … Quick TJ
  • Healthy nerve function provides humans with the control of movement; sensation (such as pain, touch and temperature) and the quality of skin, hair and nails. Injury to this complex system creates a deficit in function, which is slow to recover, and rarely, if ever, returns to what patients consider to be normal. Despite promising results in pre-clinical animal experimentation effective translatio…
  • Nanoneurotoxicity and Potential Nanotheranostics for Alzheimer's Disease. [Journal Article]
    EC Pharmacol Toxicol 2019; 7(12):1-7Carro CE, Pilozzi AR, Huang X
  • Alzheimer's disease (AD) is the most common form of senile dementia and it is characterized by cognitive, motor and memory impairments. AD neuropathology includes toxic biomarkers, such as Aβ amyloid protein buildup between neurons disrupting connections, tau protein fibrillization and neuronal demise. These biomarkers are exacerbated with exposure to environmental borne or man-made nanoparticles…
  • Clinicopathologic characterization and abnormal autophagy of CSF1R-related leukoencephalopathy. [Journal Article]
    Transl Neurodegener 2019; 8:32Tian WT, Zhan FX, … Cao L
  • CONCLUSIONS: Our findings support the loss-of-function and haploinsufficiency hypothesis in pathogenesis. Autophagy abnormality may play a role in the disease. Repairing or promoting the phosphorylation level of mutant CSF1R may shed light on therapeutic targets in the future. However, whether peripheral polyneuropathy potentially belongs to CSF1R-related spectrum deserves further study with longer follow-up and more patients enrolled.
  • Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets. [Review]
    Front Cell Neurosci 2019; 13:528Ng SY, Lee AYW
  • Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality amongst civilians and military personnel globally. Despite advances in our knowledge of the complex pathophysiology of TBI, the underlying mechanisms are yet to be fully elucidated. While initial brain insult involves acute and irreversible primary damage to the parenchyma, the ensuing secondary brain injuri…
  • Human tau pathology transmits glial tau aggregates in the absence of neuronal tau. [Journal Article]
    J Exp Med 2020; 217(2)Narasimhan S, Changolkar L, … Lee VMY
  • Tauopathies are characterized by abnormal accumulation of tau protein in neurons and glia. In Alzheimer's disease (AD), tau aggregates in neurons, while in corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), tau also aggregates in astrocytes and oligodendrocytes. We previously demonstrated that human CBD and PSP tauopathy lysates (CBD-tau and PSP-tau) contain distinct tau st…
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