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Unbound Medicine.
(neuromodulation)
11,088 results
  • A Systematic Review of Deep Brain Stimulation Targets for Obsessive Compulsive Disorder. [Journal Article]
    Neurosurgery. 2020 Jul 02 [Online ahead of print]Raviv N, Staudt MD, … Pilitsis JG
  • CONCLUSIONS: The striatal area is the most commonly targeted region for OCD-DBS. We recommend a common nomenclature based on this review. To move the field forward to individualized therapy, active contact location relative to stereotactic coordinates and patient specific anatomical and clinical variances need to be reported.
  • Input dependent modulation of olfactory bulb activity by HDB GABAergic projections. [Journal Article]
    Sci Rep. 2020 Jul 01; 10(1):10696.Böhm E, Brunert D, Rothermel M
  • Basal forebrain modulation of central circuits is associated with active sensation, attention, and learning. While cholinergic modulations have been studied extensively the effect of non-cholinergic basal forebrain subpopulations on sensory processing remains largely unclear. Here, we directly compare optogenetic manipulation effects of two major basal forebrain subpopulations on principal neuron…
  • Sacral Neuromodulation in a Patient with Wolff-Parkinson-White Syndrome: A Case Report. [Case Reports]
    Res Rep Urol. 2020; 12:193-197.Almutairi S
  • Sacral neuromodulation has gained widespread use for bladder overactivity, frequency, urgency, fecal incontinence, and nonobstructive urinary retention; hence, implantations of this device in patients with comorbid cardiac conduction diseases have increased. Theoretically, there are some concerns regarding the use of sacral neuromodulation implants in patients with Wolf-Parkinson-White syndrome a…
  • Mechanism of Traditional Chinese Medicine in Treating Knee Osteoarthritis. [Review]
    J Pain Res. 2020; 13:1421-1429.Wang M, Liu L, … Li B
  • Knee osteoarthritis (KOA) is a degenerative disease, making a unique contribution to chronic pain, edema, and limited mobility of knee joint. Traditional Chinese Medicine (TCM) is a common complementary therapy for KOA and has been found effective. The aim of this review is to consolidate the current knowledge about the mechanism of four interventions of TCM: acupuncture, moxibustion, herbs, and …
  • DEPRESSION AND CARDIOVASCULAR AUTONOMIC CONTROL: A MATTER OF VAGUS AND SEX PARADOX. [Review]
    Neurosci Biobehav Rev. 2020 Jun 26 [Online ahead of print]Tobaldini E, Carandina A, … Montano N
  • Depression is a well-established stress-related risk factor for several diseases, mainly for those with cardiovascular outcomes. The mechanisms that link depression disorders with cardiovascular diseases (CVD) include dysfunctions of the autonomic nervous system. Heart rate variability analysis is a widely-used non-invasive method that can simultaneously quantify the activity of the two branches …
  • Functional segregation within the pelvic nerve of male rats: a meso- and microscopic analysis. [Journal Article]
    J Anat. 2020 Jun 29 [Online ahead of print]Bertrand MM, Korajkic N, … Keast JR
  • The pelvic splanchnic nerves are essential for pelvic organ function and have been proposed as targets for neuromodulation. We have focused on the rodent homologue of these nerves, the pelvic nerves. Our goal was to define within the pelvic nerve the projections of organ-specific sensory axons labelled by microinjection of neural tracer (cholera toxin, subunit B) into the bladder, urethra or rect…
  • Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group. [Review]
    Hum Brain Mapp. 2020 Jun 29 [Online ahead of print]Zugman A, Harrewijn A, … Winkler AM
  • The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and im…
  • Supplementary motor area functional connectivity in "drug-naïve" Parkinson's disease patients with fatigue. [Journal Article]
    J Neural Transm (Vienna). 2020 Jun 27 [Online ahead of print]Siciliano M, De Micco R, … Tessitore A
  • Fatigue is a common and disabling nonmotor manifestation in patients with Parkinson's disease (PD), and the supplementary motor area (SMA) has been implicated in its pathophysiology. SMA is usually divided in its rostro-caudal axis, with the rostral (pre-) SMA playing a major role in motor planning, and the caudal (proper) SMA related to movement execution. To investigate brain functional connect…
  • Sacral neuromodulation for overactive bladder in women: do age and comorbidities make a difference? [Journal Article]
    Int Urogynecol J. 2020 Jun 25 [Online ahead of print]High RA, Winkelman W, … Danford JM
  • CONCLUSIONS: Most women have successful sacral neuromodulation trials despite older age and comorbidities. Higher decade of age has a negative effect on odds of implantation and is associated with addition of therapies post-implantation. Comorbidities assessed in this study did not affect implantation or addition of therapies post-implantation. Most women add therapies to improve efficacy post-implantation, and explantation rates are low.
  • Parkinsonian Syndrome with Frontal Lobe Involvement and Anti-Glycine Receptor Antibodies. [Case Reports]
    Brain Sci. 2020 Jun 23; 10(6)Endres D, Prüss H, … Tebartz van Elst L
  • Background: Atypical Parkinsonian syndromes with prominent frontal lobe involvement can occur in the 4R-taupathies progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Secondary forms of movement disorders may occur in the context of autoimmune encephalitis with antineuronal antibodies, such as anti-glycine receptor (anti-GlyR) antibodies, which are typically associated with…
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