- Overlap of systemic lupus erythematosus and myositis is rare in anti-Ku antibody-positive patients. [Letter]Ann Rheum Dis 2019AR
- Comparing the burdens of opportunistic infections among patients with systemic rheumatic diseases: a nationally representative cohort study. [Journal Article]Arthritis Res Ther 2019; 21(1):211AR
- CONCLUSIONS: The risk of opportunistic infection was highest for PM/DM, followed by SLE, SSc, RA, and pSS. Careful observation and preventive therapy for opportunistic infections may be warranted in selected PM/DM patients, especially during the first year after the diagnosis.
- A Mutation in the Mitochondrial Aspartate/Glutamate Carrier Leads to Intramitochondrial Oxidation and an Inflammatory Myopathy in Dutch Shepherd Dogs. [Journal Article]J Neuromuscul Dis 2019JN
- CONCLUSIONS: This study provides the first description of a metabolic mechanism in which ablated mitochondrial glutamate transport markedly reduced the import of reducing equivalents into mitochondria and produced a highly oxidizing and proinflammatory muscle environment and an inflammatory myopathy.
- [Clinical value of myositis antibodies in patients with connective tissue disease-associated interstitial lung diseases]. [Journal Article]Zhonghua Jie He He Hu Xi Za Zhi 2019; 42(10):765-770ZJ
- CONCLUSIONS: Myositis antibody profiling should be performed in patients with ILD who were negative for conventional autoimmune antibody testing and had no CTD. In patients with SS-ILD and UCTD-ILD, the myositis antibody spectrum could detect the presence of myositis-specific antibodies and myositis-related antibodies in some patients, and its role in clinical diagnosis and treatment needed further observation.
- Safety and efficacy of PD-1/PD-L1 blockade in patients with preexisting antinuclear antibodies. [Journal Article]Clin Transl Oncol 2019CT
- CONCLUSIONS: Further studies to identify predictive factors for the development of irAEs are required to provide relevant patient care and maximize the therapeutic benefits of ICIs.
- Hemophagocytic Lymphohistiocytosis ： A Skeleton in the Cupboard of Adult Idiopathic Inflammatory Myopathies. [Journal Article]J Rheumatol 2019JR
- CONCLUSIONS: In this study, secondary HLH was a fatal complication with higher on-admission disease activity, AE-ILD and infection working as risk factors. The underlying role of infection and autoimmune abnormality in HLH in connective tissue disease (CTD) was subsequently brought up. Clinical factors influencing the short-term outcome of patients with secondary HLH required further exploration.
- Preterm birth phenotypes in women with autoimmune rheumatic diseases: A population based cohort study. [Journal Article]BJOG 2019BJOG
- CONCLUSIONS: Women with systemic autoimmune diseases appear to have an elevated risk of various PTB phenotypes. Therefore, preconception counseling and close monitoring during pregnancy is crucial.
- [Dermatomyositis and rectal cancer: case study and literature review]. [Case Reports]Pan Afr Med J 2019; 33:122PA
- Dermatomyositis is a systemic idiopathic disease characterized by a combination of both muscle and skin symptoms. It is a paraneoplastic dermatosis. Its association with rectal cancer has been rarely described in the literature. We here report the case of a female patient with paraneoplastic dermatomyositis associated with metastatic rectal adenocarcinoma presenting with clinical symptoms commonl…
Dermatomyositis is a systemic idiopathic disease characterized by a combination of both muscle and skin symptoms. It is a paraneoplastic dermatosis. Its association with rectal cancer has been rarely described in the literature. We here report the case of a female patient with paraneoplastic dermatomyositis associated with metastatic rectal adenocarcinoma presenting with clinical symptoms commonly found in subjects with paraneoplastic dermatomyositis. Other complementary examinations (CPK test + EMG + skin biopsy) were performed which confirmed this diagnosis. The patient underwent chemotherapy, but after the second cycle, she experienced a rapid worsening of her general condition and died after some days in a state of multisystem organ failure. This study aims to highlight paraneoplastic dermatomyositis' aggressive nature and to update current knowledge on the importance of chemotherapy in the management of neoplastic dermatomyositis.
- Imaging of Thoracic Wall Abnormalities. [Case Reports]Korean J Radiol 2019; 20(10):1441-1453KJ
- Identification of certain abnormalities of the chest wall can be extremely helpful in correctly diagnosing a number of syndromic conditions and systemic diseases. Additionally, chest wall abnormalities may sometimes constitute diagnoses by themselves. In the present pictorial essay, we review a number of such conditions and provide illustrative cases that were retrospectively identified from our …
Identification of certain abnormalities of the chest wall can be extremely helpful in correctly diagnosing a number of syndromic conditions and systemic diseases. Additionally, chest wall abnormalities may sometimes constitute diagnoses by themselves. In the present pictorial essay, we review a number of such conditions and provide illustrative cases that were retrospectively identified from our clinical imaging database. These include pentalogy of Cantrell, Klippel-Feil syndrome, cleidocranial dysplasia, Poland syndrome, osteopetrosis, neurofibromatosis type 1, Marfan syndrome, Gardner syndrome, systemic sclerosis, relapsing polychondritis, polymyositis/dermatomyositis, ankylosing spondylitis, hyperparathyroidism, rickets, sickle cell anemia, thalassemia, tuberculosis, septic arthritis of the sternoclavicular joint, elastofibroma dorsi, and sternal dehiscence.
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- The heart of anti-Ku related disease: extensive review and meta-analysis. Response to: 'Anti-Ku syndrome with elevated CK: association with myocardial involvement in systemic sclerosis' by Campochiaro et al. [Journal Article]Ann Rheum Dis 2019AR