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767 results
  • Waves in Extremities: A Rare Report of Isolated Isaacs' Syndrome. [Case Reports]
    Cureus 2019; 11(5):e4687Bin Waqar SH
  • Isaacs' syndrome is a rare neuromuscular hyperexcitable syndrome with myriad manifestations ranging from motor and sensory to autonomic presentations, leading to diagnostic challenges. Among the commonest forms, a tetrad of stiffness, myokymia (muscle twitching at rest), weakness, and psuedomyotonia (delayed muscle relaxation) is almost always present. Herein, we report a case of a 16-year-old ma…
  • Peripheral nerve hyperexcitability. [Journal Article]
    Handb Clin Neurol 2019; 161:281-290Katirji B
  • Neuromyotonic and myokymic discharges are abnormal electrical muscular discharges caused by ectopic discharges from motor axons and represent the hallmarks of peripheral nerve hyperexcitability. Neuromyotonic discharges are specific for peripheral nerve hyperexcitability syndromes, whereas myokymic discharges may occur either focally or in a more generalized fashion in many other peripheral nerve…
  • Autoimmune Channelopathies at Neuromuscular Junction. [Review]
    Front Neurol 2019; 10:516Huang K, Luo YB, Yang H
  • The neuromuscular junction, also called myoneural junction, is a site of chemical communication between a nerve fiber and a muscle cell. There are many types of channels at neuromuscular junction that play indispensable roles in neuromuscular signal transmission, such as voltage-gated calcium channels and voltage-gated potassium channels on presynaptic membrane, and acetylcholine receptors on pos…
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