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698,984 results
  • Model-based optimized phase-deviation deep brain stimulation for Parkinson 's disease. [Journal Article]
    Neural Netw 2019; 122:308-319Yu Y, Hao Y, Wang Q
  • High-frequency deep brain stimulation (HF-DBS) of the subthalamic nucleus (STN), globus pallidus interna (GPi) and globus pallidus externa (GPe) are often considered as effective methods for the treatment of Parkinson's disease (PD). However, the stimulation of a single nucleus by HF-DBS can cause specific physical damage, produce side effects and usually consume more electrical energy. Therefore…
  • Role of monocarboxylate transporter 4 in Alzheimer disease. [Journal Article]
    Neurotoxicology 2019Hong P, Zhang X, … Wang P
  • The pathological process of Alzheimer disease (AD) is closely related to energy metabolism disorders. In the nervous system, monocarboxylate transporter 4 (MCT4) is expressed in the glial cell membrane and is responsible for transporting intracellular lactic acid. In this study, we found that MCT4 expression was elevated in the cerebrospinal fluid of patients with mild cognitive impairment. Two- …
  • Metabolic Regulation of Hippocampal Neuroprogenitor Apoptosis After Irradiation. [Journal Article]
    J Neuropathol Exp Neurol 2019Li YQ, Koritzinsky M, Wong CS
  • The tumor suppressor p53 is an important regulator of cell fate response after DNA damage. Cell fate response following metabolic stresses has also been linked to p53-dependent pathways. In this study, we asked if 5'-adenosine monophosphate-activated protein kinase (AMPK), the master sensor of cellular energy balance, played a role in p53-dependent apoptosis of neural progenitor cells (NPCs) in t…
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